Malnutrition in gastrointestinal cancer manifests before systemic therapy and is associated with fatigue and reduced physical quality of life
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Le résumé fourni par la source
BACKGROUND: There is a high malnutrition risk in patients with gastrointestinal tumors. Yet it is unknown when malnutrition manifests and how changes in nutritional status are related to quality of life and fatigue at different stages of oncologic therapy. PATIENTS AND METHODS: In a prospective observational study, we recruited patients with initial diagnosis of any gastrointestinal tumor requiring systemic therapy and respective patients already receiving treatment. Subjects underwent comprehensive nutritional assessment at enrollment and after 3 months. In addition, patients reported data on physical activity (IPAQ-SF), quality of life (SF-12), and fatigue (EORTC QLQ-FA12). Besides baseline associations, relations between changes in nutritional status and patient-reported outcomes during treatment were analyzed. RESULTS: We included 66 patients (mean(±SD) age: 62.1(±10.6) yrs.; 68% male), of which 29 had received initial diagnosis and 37 were already undergoing treatment. Baseline clinical characteristics and nutritional status were comparable between groups. With 88% of patients, GLIM-defined malnutrition was highly prevalent at baseline and associated with fatigue, reduced physical activity, and quality of life (P < .01, respectively). Among 36 study completers, only minor fat mass (P = .033) and progressed weight loss (P = .025) indicated further nutritional deterioration. Development of cachexia, but not malnutrition or sarcopenia, during treatment was associated with impaired patient-reported outcomes, ie, higher fatigue (rho = 0.400; P = .019) and lowered physical activity (rho=-0.423; P = .013). CONCLUSION: Most patients with gastrointestinal cancer are malnourished already at diagnosis. Impaired nutritional status is closely linked with reduced quality of life and fatigue, especially their physical components. Trials are warranted to test whether optimized nutrition support can halt further aggravation during treatment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Malnutrition in gastrointestinal cancer manifests before systemic therapy and is associated with fatigue and reduced physical quality of life
- Date Crossref
- 03/02/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universitätsmedizin Greifswald pays non établi dans la noticeÉtablissement de santé
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Universität Greifswald pays non établi dans la noticeUniversité ou école supérieure
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FH Münster pays non établi dans la noticeUniversité ou école supérieure
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University Children's Hospital Zurich pays non établi dans la noticeÉtablissement de santé
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Neubrandenburg University of Applied Sciences pays non établi dans la noticeUniversité ou école supérieure
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Ludwig-Maximilians-Universität München pays non établi dans la noticeUniversité ou école supérieure
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University of Applied Sciences Münster Department of Food Nutrition Facilities pays non établi dans la noticeUniversité ou école supérieure
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University Medicine Greifswald Department of Medicine A pays non établi dans la noticeUniversité ou école supérieure
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University of Applied Sciences Neubrandenburg Institute of Evidence-based Dietetics (NIED) pays non établi dans la noticeUniversité ou école supérieure
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University Hospital pays non établi dans la noticeUniversité ou école supérieure
Universitätsmedizin Greifswald, Universität Greifswald et FH Münster, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.