Effects of supplementation with two probiotic strains on metabolic profile, hormonal status, oxidative stress, and quality of life in women with polycystic ovary syndrome: A study protocol for a randomized clinical trial
Rattachement africain : ir, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women, associated with insulin resistance, ovulatory dysfunction, hyperandrogenism, and inflammation. Current treatments often focus on symptoms rather than underlying causes, emphasizing the need for comprehensive strategies. Recently, probiotics have emerged as a safe and cost-effective nutritional option for managing metabolic issues. Objective: This study aims to evaluate the effects of Lactobacillus helveticus and Bifidobacterium longum supplementation on the cardiometabolic profile, hormonal status, oxidative stress, and quality of life in women with PCOS. Materials and Methods: We will conduct a double-blind, placebo-controlled, randomized trial involving 90 women with PCOS from Shahid Beheshti hospital, Isfahan, Iran. Recruitment will begin on June 20, 2024, and is expected to be completed by June 20, 2025. Participants will be randomly assigned to receive either a daily probiotic capsule containing Lactobacillus helveticus and Bifidobacterium longum or a placebo. The study will assess the impact of these probiotic strains on cardiometabolic profile, hormonal status, oxidative stress, mental health, quality of life, sleep quality, and clinical symptoms in women with PCOS. All parameters will be evaluated before and after the intervention. Discussion: Elevated insulin levels and gut microbiota imbalances significantly contribute to the development of PCOS. Growing evidence suggests that gut dysbiosis is linked to sex hormone levels and estrous cycles. We hypothesize that probiotic supplementation in individuals with PCOS will improve hormonal, metabolic, inflammatory, and antioxidant markers compared to those receiving a placebo.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of supplementation with two probiotic strains on metabolic profile, hormonal status, oxidative stress, and quality of life in women with polycystic ovary syndrome: A study protocol for a randomized clinical trial
- Date Crossref
- 27/01/2026
- Éditeur
- Knowledge E DMCC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Isfahan University of Medical Sciences Nutrition and Food Security Research Center pays non établi dans la noticeUniversité ou école supérieure
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Shahid Sadoughi University of Medical Sciences and Health Services Nutrition and Food Security Research Center pays non établi dans la noticeUniversité ou école supérieure
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Shiraz University pays non établi dans la noticeUniversité ou école supérieure
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University of Nevada pays non établi dans la noticeUniversité ou école supérieure
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School of Nutrition and Food Science Department of Community Nutrition pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Research Center for Food Hygiene and Safety pays non établi dans la noticeUniversité ou école supérieure
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School of Agriculture Department of Food Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Kirk Kerkorian School of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Nutrition and Food Security Research Center — Isfahan University of Medical Sciences, Nutrition and Food Security Research Center — Shahid Sadoughi University of Medical Sciences and Health Services et Shiraz University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.