Mendelian randomization and bioinformatics analysis identify the association between plasma proteins and cataract
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Le résumé fourni par la source
Previous observational studies have indicated a significant correlation between plasma proteome composition and cataract pathological status; however, the direction of causality remains uncertain. In light of the aforementioned findings, the present study employs a bidirectional two-sample Mendelian randomisation strategy, with the objective of elucidating the direct causal link between plasma proteome changes and cataract development. Following rigorous data analysis and validation, a series of plasma proteins were identified as being strongly associated with cataract risk. These included ILF3, FAM171A1, ARHGEF2, LPR1B, CRYGD, GLT8D1, ARHGEF10 and LRRTM1, all of which were confirmed to be potential risk factors for cataract. In contrast, proteins such as MXRA7, ZHX3, SPAG11B, ARID1A, DNASE1L2, COX7A1 and EEF2K were found to exert a protective effect against cataract. To gain further insight into the specific mechanisms by which these causally related proteins contribute to cataract pathology, we subsequently performed an exhaustive bioinformatics analysis. This analysis not only deepened our understanding of the functional properties of these proteins, but also revealed their possible involvement in signalling pathways and molecular interactions, thereby providing new insights into the pathogenesis of cataract.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Mendelian randomization and bioinformatics analysis identify the association between plasma proteins and cataract
- Date Crossref
- 17/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chengdu University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Hubei Provincial Hospital of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
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Leshan Normal University pays non établi dans la noticeUniversité ou école supérieure
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Wuhan City Chinese Medicine Hospital pays non établi dans la noticeÉtablissement de santé
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Leshan City Hospital of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
Chengdu University of Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine et Leshan Normal University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.