Efficacy and safety of dapsone in adult immune thrombocytopenia: a systematic review and meta-analysis
Rattachement africain : pk, in, jo, af. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune condition often managed with corticosteroids, intravenous immunoglobulins, or thrombopoietin receptor agonists. In settings where these therapies are inaccessible or contraindicated, dapsone an older antimicrobial agent with immunomodulatory effects has been proposed as an alternative, though its comparative effectiveness and safety profile remain inadequately defined. OBJECTIVES: This study systematically reviews and synthesizes existing data to assess the efficacy and tolerability of dapsone in adult patients with ITP. METHODS: Following PRISMA guidelines, a literature search across PubMed, Embase, and Cochrane databases identified observational studies and interventional trials evaluating dapsone in ITP, including comparisons with standard treatments. Primary outcomes included complete and overall response rates, hemoglobin variation, relapse frequency, and adverse effects. Risk of bias was evaluated using the Newcastle-Ottawa Scale and Cochrane tools. Meta-analysis was conducted using RevMan and R (meta/metafor). RESULTS: Four eligible studies encompassing over 270 patients were analyzed. The pooled complete response rate was 28%, while the overall response rate reached 47%. Dapsone use was associated with a modest decline in hemoglobin levels with a mean decrease of 1.74 g/dL, and relapse occurred in approximately 21% of patients. Adverse effects most commonly hemolytic anemia and methemoglobinemia were reported in 18% of patients, though generally not severe. Heterogeneity was explored through leave-one-out sensitivity analyses. CONCLUSIONS: Dapsone demonstrates moderate efficacy and an acceptable safety profile in adult ITP patients, especially in resource-limited contexts. While it may not match thrombopoietin agonists in preventing relapse, its low cost and oral administration offer practical advantages. Further large-scale randomized trials are warranted to clarify its role in ITP management.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efficacy and safety of dapsone in adult immune thrombocytopenia: a systematic review and meta-analysis
- Date Crossref
- 11/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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CMH Lahore Medical College and Institute of Dentistry pays non établi dans la noticeÉtablissement de santé
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Nishtar Medical College and Hospital pays non établi dans la noticeInstitution
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All India Institute of Medical Sciences Bhubaneswar pays non établi dans la noticeUniversité ou école supérieure
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Rawalpindi Medical University pays non établi dans la noticeÉtablissement de santé
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Khyber Medical College pays non établi dans la noticeÉtablissement de santé
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Khyber Girls Medical College pays non établi dans la noticeUniversité ou école supérieure
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King Edward Medical University pays non établi dans la noticeUniversité ou école supérieure
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University of Jordan pays non établi dans la noticeUniversité ou école supérieure
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Jinnah Sindh Medical University pays non établi dans la noticeUniversité ou école supérieure
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Kandahar University pays non établi dans la noticeUniversité ou école supérieure
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FMH College of Medicine and Dentistry pays non établi dans la noticeUniversité ou école supérieure
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Multan Medical and Dental College pays non établi dans la noticeUniversité ou école supérieure
CMH Lahore Medical College and Institute of Dentistry, Nishtar Medical College and Hospital et All India Institute of Medical Sciences Bhubaneswar, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.