Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers
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Background Many patients with bipolar disorder (BD) report cognitive problems. Pathophysiology of cognitive impairment in BD is unclear, although prevalence of dementia in BD is high. In Older-Age Bipolar Disorder (OABD) patients with cognitive complaints, neurodegeneration may play a role. This could occur in at least 2 ways: (1) BD with ‘comorbid’ diagnosis of dementia; (2) specific neurobiological processes can underlie a cognitive impairment that is intrinsic of BD (ie, BD-related cognitive impairment). Methods 102 OABD patients were selected from the Amsterdam Dementia Cohort study. Diagnostic workup included clinical and neuropsychological assessment, CSF biomarkers and MRI visual rating scales. About half of patients had depressive symptoms. We (1) examined which neurological diagnoses were identified by the memory clinic as the main cause of cognitive complaints. Subsequently, (2) in the remaining OABD patients with an unknown cause, we performed linear regression between biomarkers of neurodegeneration and composite cognitive score. Results 29 OABD patients (28.4%) received a neurological diagnosis, 6 of which Alzheimer’s Disease. In the remaining 73 (71.6%) OABD patients, a lower Aβ 42 CSF concentration was related to lower composite cognitive scores (B = −0.143, P = 0.034), whereas CSF T-Tau, P-Tau, and MRI markers were not. Conclusion In most OABD patients visiting a memory clinic, a neurological cause of cognitive complaints was not identified despite extensive diagnostic work-up. Altered amyloid metabolism may be an extra biological factor in the multifactorial puzzle that is BD-related cognitive impairment. Future studies should investigate a large range of biomarkers in relation to cognition in BD, including amyloid.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers
- Date Crossref
- 06/12/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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GGZ inGeest pays non établi dans la noticeOrganisme public
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Vrije Universiteit Amsterdam Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Amsterdam UMC Location Vrije Universiteit Amsterdam pays non établi dans la noticeÉtablissement de santé
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Amsterdam Neuroscience pays non établi dans la noticeStructure de recherche
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University Medical Center Utrecht Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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Amsterdam Public Health Research Institute pays non établi dans la noticeStructure de recherche
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Amsterdam UMC Location VUmc pays non établi dans la noticeInstitution
GGZ inGeest, Department of Psychiatry — Vrije Universiteit Amsterdam et Amsterdam UMC Location Vrije Universiteit Amsterdam, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.