Accès ouvert déclaré
2025
article
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur‐Lombardelli, Sonya Hessey, Kai‐Keen Shiu, John Bridgewater, Daniel Hochhauser, Martin Förster, Siow Ming Lee, Tanya Ahmad, Dionysis Papadatos-Pastos, Sam M. Janes, Katey S.S. Enfield, Nicholas McGranahan, Ariana Huebner, Sergio A. Quezada, Stephan Beck, Tariq Enver, Robert E. Hynds, David R. Pearce, Mary Falzon, Ian Proctor, Ron Sinclair, Chi-wah Lok, Zoe Rhodes, David Moore, Teresa Marafioti, Miriam Mitchison, Peter Ellery, Monica Sivakumar, Mark Linch, Sebastian Brandner, Andrew Rowan, Crispin T. Hiley, Selvaraju Veeriah, Heather M. Shaw, G. Attard, Antonia Toncheva, Paulina Prymas, Thomas B.K. Watkins, C. Donovan Bailey, Kevin Litchfield, Maise Al-Bakir, Nnenna Kanu, Sophia Ward, Emilia L. Lim, James L. Reading, Benny Chain, Blanca Trujillo Alba, Tom Watkins, Melek Akay, Dhruva Biswas, Oriol Pich, Michelle Dietzen, Clare Puttick, Emma Colliver, Mihaela Angelova, James R. Black, Olivia Lucas, William Hill, Wing-Kin Liu, Alexander M. Frankell, Neil Magno, Foteini Athanasopoulou, Roberto Salgado, Claudia Lee, Kristiana Grigoriadis, Othman Al‐Sawaf, Takahiro Karasaki, Imran Noorani, Sarah Benafif, Vittorio Barbè, Supreet Kaur Bola, Osvaldas Vainauskas, Anna Wingate, Daniel Wetterskog, Mahedi Hasan, Stefano Lise, Gianmarco Leone, Anuradha Jayaram, Constantine Alifrangis, Ursula McGovern, Kerstin Thol, Samuel Gamble, Seng Kuong Anakin Ung, Teerapon Sahwangarrom, Claudia Peinador Marin, Sophia Wong, Piotr Pawlik, Jie Min Lam, Corentin Richard, Roberto Vendramin, Krijn K. Dijkstra, Jayant K. Rane, Jérôme Nicod, Rija Zaidi, Faye Gishen, Adrian Tookman, Paddy Stone, Caroline Stirling, Samra Turajlic, James Larkin, Lisa Pickering, Andrew Furness, Kate Young, Will Drake, Kim Edmonds, Nikki Hunter, Mary Mangwende, Karla Pearce, Lauren Au, Lavinia Spain, Scott T.C. Shepherd, Haixi Yan, Benjamin Shum, Zayd Tippu, Brian Hanley, Charlotte Spencer, Max Emmerich, Camille L. Gérard, Andreas M. Schmitt, Lyra Del Rosario, Eleanor Carlyle, Charlotte Lewis, Lucy Holt, Analyn Lucanas, Molly O’Flaherty, Steve Hazell, Hardeep Singh Mudhar, Christina Messiou, Arash Latifoltojar, Annika Fendler, Fiona Byrne, Husayn Pallinkonda, Irene Lobón, Alex Coulton, Anne Laure Cattin, Daqi Deng, Geoffrey Hugang Feng, Andew Rowan, Nadia Yousaf, Sanjay Popat, Olivia Curtis, Charlotte Milner-Watts, Gordon Stamp, Emma Nye, Aida Murra, Justine Korteweg, D. F. Kelly, Lauren Terry, Jennifer Biano, Kema Peat, Kayleigh Kelly, Peter Hill, Debra H. Josephs, Sheeba Irshad, James Spicer, Ula Mahadeva, Anna Green, Ruby M. Stewart, Natasha Wright, Georgina Pulman, Ruxandra Mitu, Sherene Phillips-Boyd, Deborah Enting, Sarah Rudman, Sharmistha Ghosh, Lena Karapagniotou, Elias Pintus, Andrew Tutt, Sarah Howlett, James D. Brenton, Carlos Caldas, Rebecca C. Fitzgerald, Merche Jimenez-Linan, Elena Provenzano, Alison D. Cluroe, Anna Paterson, Sarah J. Aitken, Kieren Allinson, Grant S. Stewart, Ultan McDermott, Emma Beddowes, Tim Maughan, Olaf Ansorge, Peter J. Campbell, Patricia Roxburgh, Sioban Fraser, Kevin Blyth, John Le Quesne, Matthew Krebs, Fiona Blackhall, Yvonne Summers, Pedro Oliveira, Ana Ortega-Franco, Caroline Dive, Fábio Gomes, Mat Carter, Jo Dransfield, Anne Thomas, Dean Fennell, Jacqui Shaw, Babu Naidu, Shobhit Baijal, Bruce Tanchel, Gerald Langman, Andrew Robinson, Martin Collard, Peter Cockcroft, Charlotte Ferris, Hollie Bancroft, Amy Kerr, Gary Middleton, Joanne Webb, Salma Kadiri, Peter Colloby, Bernard Olisemeke, Rodelaine Wilson, Ian Tomlinson, Sanjay Jogai, Samantha K. Holden, Tânia Rita Moreno de Oliveira Fernandes, Iain A. McNeish, Blanche Hampton, Mairead McKenzie, Allan Hackshaw, Abby Sharp, Kitty S. Chan, Laura Farrelly, Hayley Bridger, Rachel Leslie, Mariam Jamal‐Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M. Flanagan, Peter Van Loo
4Citations signalées, ce qui n’est pas une note de qualité
10Institutions déclarées
3Pays d’affiliation déclarés
Rattachement africain : gb, dk, us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
- Date Crossref
- 26/11/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
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