Accès ouvert
2025
article
OpenAlex
William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum et autres
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the …
gb, dk, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Francisco Gimeno-Valiente, Carla Castignani, Elizabeth Larose Cadieux, Nana Mensah et autres
Abstract Aberrant DNA methylation has been described in nearly all human cancers, yet its interplay with genomic alterations during tumor evolution is poorly understood. To explore this, we performed reduced representation bisulfite sequencing on 217 tumor and matched normal regions from 59 …
gb, cn, us, it, ca, de, dk, sg
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Lydia Liu, Kerstin Haase, Aino‐Maija Leppä, Alexander Azizi et autres
Abstract Lung cancer continues to be a leading cause of cancer-related incidence and mortality worldwide. High genomic intratumour heterogeneity (ITH) has been identified as a driving mechanism of therapeutic resistance and treatment failure, and hence presents a clinical challenge. In lung cancer, …
gb
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sonya Hessey, Mihaela Angelova, Emma Colliver, Katey S.S. Enfield et autres
Abstract Deciphering the changes in the tumor and tumor microenvironment (TME) that accompany metastatic disease progression is essential if we are to identify potential new anti-cancer treatments. In particular, a complete understanding of how cancer subclones and TME evolve over time from …
gb, be
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
James R. Black, Gábor Bartha, Charles W. Abbott, Sean Michael Boyle et autres
Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically validated for ultrasensitive ctDNA detection …
gb, us, jp, it, nl, de, dk, hu
(code pays fourni par la source)
Accès ouvert
2020
dataset
OpenAlex
Michele Bortolomeazzi, Mohamed Reda Keddar, Lucia Montorsi, Lorena Benedetti et autres
Immunogenomics of colorectal cancer response to immune checkpoint blockade TCR-seq data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" Both files were downloaded from the Adaptive Biotechnologies immunoSeq Analyzer portal on 17/12/2019. RearrangementDetails_12-17-2019_9-06-47_AM.tsv: contains the detailed productive rearrangement …
gb, es
(code pays fourni par la source)
Accès ouvert
2020
dataset
OpenAlex
Michele Bortolomeazzi, Mohamed Reda Keddar, Lucia Montorsi, Lorena Benedetti et autres
Immunogenomics of colorectal cancer response to immune checkpoint blockade TCR-seq data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" Both files were downloaded from the Adaptive Biotechnologies immunoSeq Analyzer portal on 17/12/2019. RearrangementDetails_12-17-2019_9-06-47_AM.tsv: contains the detailed productive rearrangement …
gb, es
(code pays fourni par la source)
Accès ouvert
2020
dataset
OpenAlex
Michele Bortolomeazzi, Mohamed Reda Keddar, Lucia Montorsi, Lorena Benedetti et autres
Immunogenomics of colorectal cancer response to immune checkpoint blockade Imaging Mass Cytometry data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" The provided data includes: Sample metadata: Raw_txt_mcd_files.tar.gz/Metadata.csv Raw ablation data in .mcd or .txt format: Raw_txt_mcd_files.tar.gz Thresholded …
gb, es
(code pays fourni par la source)
Accès ouvert
2020
dataset
OpenAlex
Michele Bortolomeazzi, Mohamed Reda Keddar, Lucia Montorsi, Lorena Benedetti et autres
Immunogenomics of colorectal cancer response to immune checkpoint blockade Imaging Mass Cytometry data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" The provided data includes: Sample metadata: Raw_txt_mcd_files.tar.gz/Metadata.csv Raw ablation data in .mcd or .txt format: Raw_txt_mcd_files.tar.gz Thresholded …
gb, es
(code pays fourni par la source)