Excel datasheet showing raw EMG data acquired during colonic distensions
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Le résumé fourni par la source
Background: Enhanced colorectal sensitivity (i.e. visceral hypersensitivity) is thought to be a pathophysiological mechanism in irritable bowel syndrome (IBS). In healthy men a circadian variation in rectal perception to colonic distention was described. Disturbed day and night rhythms, which occur in shift work and trans meridian flights, are associated with the prevalence of IBS. This raises the question whether disruptions of circadian control are responsible for the observed pathology in IBS. Prior to investigating altered rhythmicity in relation to visceral hypersensitivity in a rat model for IBS, it is relevant to establish whether normal rats display circadian variation similar to healthy men. Methodology and findings: In rodents colorectal distension leads to reproducible contractions of abdominal musculature. We used quantification of this so called visceromotor response (VMR) by electromyography (EMG) to assess visceral sensitivity in rats. We assessed the VMR in normal male Long Evans rats at different time points of the light/dark cycle. Although a control experiment with male maternal separated rats confirmed that intentionally inflicted (i.e. stress induced) changes in VMR can be detected, normal male Long Evans rats showed no variation in VMR along the light/dark cycle in response to colorectal distension. Conclusions: In the absence of a daily rhythm of colorectal sensitivity in normal control rats it is not possible to investigate possible aberrancies in our rat model for IBS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Excel datasheet showing raw EMG data acquired during colonic distensions
- Date Crossref
- 24/11/2025
- Éditeur
- F1000 Research Ltd
- Type
- dataset
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Asser Institute pays non établi dans la noticeOrganisation à but non lucratif
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Amsterdam UMC Location University of Amsterdam Department of Endocrinology and Metabolism pays non établi dans la noticeÉtablissement de santé
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University of Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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Tytgat Institute for Liver and Intestinal research Department of Gastroenterology and Hepatology pays non établi dans la noticeStructure de recherche
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Tongji Medical College Department of Neurobiology pays non établi dans la noticeUniversité ou école supérieure
Asser Institute, Department of Endocrinology and Metabolism — Amsterdam UMC Location University of Amsterdam et University of Amsterdam, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.