Impact of the POPulation Medicine Multimorbidity Intervention in Xishui County (POPMIX) on suspected asthma patients: protocol for the POPMIX-Asthma cluster-randomized controlled trial
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Le résumé fourni par la source
BACKGROUND: Asthma is a common chronic disease responsible for a considerable disease burden in China and around the world. Despite its burden, there is substantial unmet need for asthma care, including screening, diagnosis, treatment, and management. Symptom-based screening for asthma could support identification of undiagnosed asthma patients, as well as reference to higher-level hospitals for formal diagnoses and treatment. This study focuses on identifying suspected asthma patients and encouraging them to seek formal diagnoses and treatment. This approach aligns with the novel concept of population medicine, which aims to maximize overall population health rather than focusing on individual patients within the health system. METHODS: We are conducting a two-arm population-based stratified clustered randomized controlled trial (cRCT) to evaluate the effectiveness of a population medicine multimorbidity intervention package. The intervention integrates community screening, chronic disease management, patient education, digital follow-up, and team-based care. The trial is being implemented in Xishui County, Guizhou Province, a mountainous low-resource county in Southwestern China, covering 26 townships and more than 300,000 permanent residents. We considered each of the 26 townships in Xishui County as a cluster and stratified them into large and small townships based on population size. Townships with an above-average population were designated as "large," and those with a below-average population were designated as "small." We randomized the same number of residents in each township stratum (large and small) to undergo the European Community Respiratory Health Survey (ECRHS) for identifying suspected asthma patients. Individuals identified as suspected asthma patients were considered study participants and subsequently enrolled in the intervention or control arm. All participants in the intervention arm are followed for one year, with one telephone follow-up at month three and in-person follow-ups at months six and 12, while participants in the control arm are followed only at baseline and 12 months. Primary outcomes include the number of chronic conditions controlled, whether the participant received lung function testing, and Asthma Control Test (ACT) score. In addition, we are evaluating 42 secondary outcomes covering physiological and functional indicators such as lung function, health-related quality of life, mental health, behavioral risk factors, healthcare utilization, productivity loss, knowledge of asthma and chronic obstructive pulmonary disease (COPD), and care cascade indicators for asthma and other chronic diseases. DISCUSSION: This cRCT has been featured as an important case study in the Lancet Commission on Investing in Health report to evaluate the effectiveness of the integrated intervention package on priority conditions. The trial was designed under population medicine principles, with an aim providing holistic care and enhancing the overall health status of suspected asthma patients. The results of the trial will inform the next generation of multimorbidity management and population medicine practices among global health authorities and practitioners. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT06457009. Registered on June 7, 2024.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of the POPulation Medicine Multimorbidity Intervention in Xishui County (POPMIX) on suspected asthma patients: protocol for the POPMIX-Asthma cluster-randomized controlled trial
- Date Crossref
- 11/04/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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China-Japan Friendship Hospital Department of Pulmonary and Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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First People’s Hospital of Zunyi pays non établi dans la noticeÉtablissement de santé
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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Peking Union Medical College Hospital pays non établi dans la noticeÉtablissement de santé
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University Hospital Heidelberg pays non établi dans la noticeÉtablissement de santé
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Guiyang Medical University pays non établi dans la noticeUniversité ou école supérieure
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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Xian Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Pennsylvania State University The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering pays non établi dans la noticeUniversité ou école supérieure
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University of Göttingen pays non établi dans la noticeUniversité ou école supérieure
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Stanford University Department of Epidemiology and Population Health pays non établi dans la noticeUniversité ou école supérieure
Department of Pulmonary and Critical Care Medicine — China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College et First People’s Hospital of Zunyi, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.