Figure 5 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Le résumé fourni par la source

B7-H3 mAb facilitates Fc receptor–dependant ADCC by stIL15-γδ T cells. A, Therapeutic apoptosis by stIL15-γδ T cells ± mAb ± mAb (Fc null), against colorectal cancer PDO 141. Two-way ANOVA with Dunnett multiple comparisons test. Mean ± SD of triplicate samples. B, Correlation between therapeutic apoptosis and B7-H3 epitope availability. The same clone of B7-H3 mAb was conjugated into the CyTOF staining panel to calculate the relative availability of B7-H3 epitope. C, EMD scores of stIL15-γδ T-cell granzyme B expression calculated relative to untreated coculture controls. One-way ANOVA with Sidak multiple comparisons test. Mean ± SD of triplicate samples. D, Decrease in stIL15-γδ T-cell % DNAM-1 expression relative to monoculture controls for each treatment. One-way ANOVA with Sidak multiple comparisons test. Mean ± SD of triplicate samples. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

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