Profil bibliographique

Kerry Ann Chester

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

267Publications signalées

6794Citations signalées

5Affiliations récentes

Les institutions déclarées

Institute of Cancer Research London Cancer Recombinant Antibody Technology (United Kingdom)CRUK Lung Cancer Centre of Excellence University College London

Les domaines associés

Monoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchGlycosylation and Glycoproteins ResearchRadiopharmaceutical Chemistry and ApplicationsHealth, Medicine and Society

Les publications récentes

Accès ouvert 2025 other OpenAlex

Figure 7 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Multimodal γδ T-cell cytotoxicity overcomes cellular therapy immunomodulation. γδ T-cell signaling networks following stIL15 transduction, coculture with PDO, and addition of B7-H3 mAb. Nodes are colored according to γδ EMD scores computed from >4 million cells across 576 conditions. Bottom, γδ cell-state …

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Data from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Abstract γδ T cells can kill cancer cells via antibody-independent cytotoxicity (AIC) and antibody-dependent cellular cytotoxicity (ADCC). A better understanding of how these cytotoxic mechanisms are affected by different cancer cells and different T-cell donors could help identify improved immunotherapeutic strategies. To …

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Figure S7 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Relationship between stIL15-γδ cytotoxicity and γδ T cell and PDO phenotypes

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Figure 2 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Single-cell phenoscaping of γδ T-cell anti-PDO cytotoxicity. A, Experimental design and PDO27 B7-H3 expression measured by flow cytometry. B, γδ T-cell EMD PHATE at phenoscape (middle) and single-cell (insets) resolution. ×180 γδ T-cell–PDO cultures. EMD scores were calculated relative to unmodified-γδ monoculture …

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Figure 1 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Secreted stIL15 supports γδ T cells without exogenous cytokines in 3D. A, Experimental design. γδ T cells were expanded from x7 healthy donors, either unmodified or transduced to overexpress stIL15, cultured in 3D without IL2 or FBS, and analyzed by TOBis MC. …

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Figure 3 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

PDOs reciprocally regulate γδ T-cell phenotypes in a patient-specific manner. A, Experimental overview. B, stIL15-γδ EMD-PHATE phenoscape annotated by PDO. EMD scores were calculated relative to stIL15-γδ monoculture controls to capture changes during γδ coculture with PDO. C, γδ T-cell PTM and …

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Figure 6 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

γδ T cells can kill chemorefractory revCSC colorectal cancer PDOs. A and B, Chemotherapy-induced apoptosis per PDO across a range of chemotherapy concentrations [SN-38, 1–100 nmol/L; 5-fluorouracil (5-FU), 0.2–200 μmol/L; oxaliplatin, 2–200 nmol/L; ref. 18]. C and D, scRNA-seq stem cell index …

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Figure S4 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

stIL15-γδs phenotype regulation by CRC PDOs with or without anti-B7-H3 mAb

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Figure S1 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

γδT cell stIL15 transduction phenotypes

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Figure 4 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Regulation of γδ T cells correlates with anti-PDO cytotoxicity. A, Single-cell PHATE of x10 PDOs + stIL15-γδ T cells ± B7-H3 mAb. B, PDO apoptosis via AIC or ADCC per γδ T donor across x10 PDOs. Two-way ANOVA with Sidak multiple comparisons …

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Figure 5 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

B7-H3 mAb facilitates Fc receptor–dependant ADCC by stIL15-γδ T cells. A, Therapeutic apoptosis by stIL15-γδ T cells ± mAb ± mAb (Fc null), against colorectal cancer PDO 141. Two-way ANOVA with Dunnett multiple comparisons test. Mean ± SD of triplicate samples. B, …

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Figure S3 from Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation

Callum Baird Nattress, Rhianna O’Sullivan, Daniel W. Fowler, Colin P. Hutton et autres

Phenotype of stIL15-γδ T cells when co-cultured with CRC PDO27

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