Detection and severity stratification of chronic liver disease using magnetic resonance intravoxel incoherent motion and elastography
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Le résumé fourni par la source
Abstract Background With chronic liver disease (CLD) rising globally, noninvasive methods are needed to stratify early, intermediate, and advanced CLD with and without clinically significant portal hypertension (CSPH). Purpose To analyze the combined diagnostic value of intravoxel incoherent motion (IVIM) and liver stiffness (LS) from magnetic resonance elastography (MRE) for CLD stage discrimination vs secondary single-parameter analyses. Materials and methods This retrospective cross-sectional study included 185 patients who underwent 3T liver MRI, including MRE and IVIM, between March 2016 and November 2023. Patients with CLD were grouped based on their liver fibrosis degree into early CLD (F0-F1; n = 21), intermediate CLD (F2; n = 19), advanced CLD (F3-F4, n = 20), and advanced CLD with CSPH (n = 22). CSPH was defined as splenomegaly (>120 mm) with thrombocytopenia (<100 × 109/L), ascites, or portosystemic collaterals. Patients without CLD (n = 103) served as negative controls. IVIM parameters (tissue diffusivity D, perfusion fraction f, and pseudo-diffusion coefficient D*) and MRE LS were analyzed. Statistical analysis included the Kruskal-Wallis test and both univariate and multivariate regression. Results In total, 185 patients (median age: 55 years, interquartile range 25%-75%: 45-63 years; 94 men) were evaluated. All parameters differed significantly between all groups (P < .001). f and D* decreased with disease progression, while LS increased. D initially decreased in patients with CLD but increased in those with CSPH. Consequently, higher D-values indicated the presence of CSPH in advanced stages (odds ratio [OR] 1.09, 95% CI 1.03-1.17, P = .009). Elevated LS values showed strong associations with the presence of CLD (OR 5.01, CI 2.25-12.65, P < .001). Combining D and LS further improved diagnostic differentiation between disease stages, especially for differentiation between advanced CLD and advanced CLD with CSPH (OR 2.41, CI 1.33-5.44, P = .01). Conclusion IVIM and MRE are useful for characterizing CLD and CSPH. Combining D from IVIM with LS from MRE improves diagnostic accuracy compared to MRE alone.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Detection and severity stratification of chronic liver disease using magnetic resonance intravoxel incoherent motion and elastography
- Date Crossref
- 01/11/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Bern Graduate School for Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Bern University of Applied Sciences pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Bern pays non établi dans la noticeÉtablissement de santé
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Zug Cantonal Hospital pays non établi dans la noticeÉtablissement de santé
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University of Lucerne Department of Radiology and Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Bern Department of Diagnostic pays non établi dans la noticeUniversité ou école supérieure
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Department of Radiology pays non établi dans la noticeInstitution
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Bern University Hospital Institute of Diagnostic and Interventional Neuroradiology pays non établi dans la noticeUniversité ou école supérieure
Graduate School for Health Sciences — University of Bern, Bern University of Applied Sciences et University Hospital of Bern, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.