Development and Validation of the Healthy Longevity Index for Personalized Healthy Aging in Primary Care: Cross-National Retrospective Analysis
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Le résumé fourni par la source
Background: Measuring and promoting healthy aging at an individual level remains challenging as promoting healthy longevity requires real-time, personalized tools to assess risk and guide interventions in clinical practice. Objective: This study aimed to develop and validate a novel Healthy Longevity Index (HLI) for use in primary care settings in older adults. Methods: Using data from the Taiwan Longitudinal Study on Aging (TLSA; n=4470), we developed a nomogram-based HLI incorporating demographics, lifestyle factors, intrinsic capacity (IC) measures, and chronic conditions to predict 4-, 8-, and 12-year disability- and dementia-free survival (absence of physical disability, dementia, or mortality). The HLI was internally validated in a TLSA subset and externally validated in the Japanese National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) cohort (n=1090). Results: The 12-year HLI nomogram demonstrated robust performance, with C-statistics of 0.79 (bootstrapped 95% CI 0.78-0.80) in the TLSA training cohort and 0.77 (bootstrapped 95% CI 0.75-0.79) in the TLSA validation cohort. External validation in the NILS-LSA yielded a C-statistic of 0.71 (bootstrapped 95% CI 0.66-0.76). The HLI effectively stratified participants into risk tertiles, with the highest-risk group showing only 27.8% probability of 12-year disability- and dementia-free survival compared to 87.8% in the lowest-risk group. Key predictors included age, sex, education, and, particularly, IC impairments in locomotion, visual acuity, and cognition-all assessable during routine primary care consultations. Conclusions: The HLI provides a practical tool for real-time, personalized assessment of healthy longevity risk in primary care settings. Its design enables providers to deliver person-centered care through targeted interventions and individualized prevention strategies that promote healthy aging across populations, especially in older adults.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Development and Validation of the Healthy Longevity Index for Personalized Healthy Aging in Primary Care: Cross-National Retrospective Analysis
- Date Crossref
- 03/11/2025
- Éditeur
- JMIR Publications Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Taiwan University pays non établi dans la noticeUniversité ou école supérieure
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National Center for Geriatrics and Gerontology pays non établi dans la noticeÉtablissement de santé
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National Yang Ming Chiao Tung University Center for Healthy Longevity and Aging Sciences pays non établi dans la noticeUniversité ou école supérieure
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National Taiwan University Hospital pays non établi dans la noticeÉtablissement de santé
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Taipei Veterans General Hospital Center for Geriatrics and Gerontology pays non établi dans la noticeÉtablissement de santé
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Taipei Municipal YangMing Hospital pays non établi dans la noticeÉtablissement de santé
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College of Medicine Graduate Institute of Clinical Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Department of Epidemiology of Aging pays non établi dans la noticeInstitution
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Taipei Municipal Gan-Dau Hospital pays non établi dans la noticeÉtablissement de santé
National Taiwan University, National Center for Geriatrics and Gerontology et Center for Healthy Longevity and Aging Sciences — National Yang Ming Chiao Tung University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.