Plasma branched-chain amino acids and risk of radiation-induced acute skin toxicity in women with breast cancer: results from the ATHENA project
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Le résumé fourni par la source
Background/Objectives: Little is known regarding the influence of circulating plasma branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine on acute skin toxicity (AST) after breast cancer (BC) radiotherapy. Hence, this study examined the association between circulating plasma BCAAs and the risk of ≥ grade 2 AST post-radiotherapy among BC patients. Methods: An observational study was conducted among 161 BC patients treated with radiotherapy within the ATHENA project in Italy. Plasma BCAAs were measured at 2-time points: at baseline (T0) and at the end of radiotherapy (T1) (after 3 or 5 weeks), and were ascertained using a validated method based on tandem mass spectrometry. AST was measured at T1 and defined according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment Cancer (RTOG/EORTC) criteria. Analysis was conducted in two parts with separate study designs using multivariable-adjusted logistic regression models: 1) A cross-sectional analysis explored the association between plasma BCAAs at T1 and odds of AST post-radiotherapy; 2) A prospective analysis examined the association between plasma BCAAs at T0 and odds of AST post-radiotherapy. Results: AST post-radiotherapy was observed in 45 (28%) patients. In the cross-sectional analysis, at T1, plasma isoleucine (1-SD increment) was associated with 43% reduced odds of ≥ grade 2 AST post-radiotherapy (OR = 0.57;95% CI 0.36 to 0.91). A similar trend was observed in the prospective analysis at T0 (OR = 0.65;95% CI 0.42 to 1.02). There was no evidence of an association between plasma leucine and valine with AST post-radiotherapy, either at T0 or T1. Plasma isoleucine was associated with lower odds of AST post-radiotherapy in BC patients. Conclusions: The findings highlight that plasma isoleucine is associated with a low risk of ≥ grade 2 AST post-radiotherapy among BC patients. However, further studies such as isoleucine supplementation trials are needed to validate these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Plasma branched-chain amino acids and risk of radiation-induced acute skin toxicity in women with breast cancer: results from the ATHENA project
- Date Crossref
- 20/10/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituto Neurologico Mediterraneo pays non établi dans la noticeÉtablissement de santé
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Azienda USL di Bologna pays non établi dans la noticeÉtablissement de santé
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Fondazione Edmund Mach pays non établi dans la noticeInstitution
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University of Milan pays non établi dans la noticeUniversité ou école supérieure
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LUM Jean Monnet University pays non établi dans la noticeUniversité ou école supérieure
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Research Unit of Epidemiology and Prevention pays non établi dans la noticeStructure de recherche
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Istituto di Radiologia pays non établi dans la noticeInstitution
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Responsible Research Hospital Radiotherapy Unit pays non établi dans la noticeÉtablissement de santé
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Radiation Oncology pays non établi dans la noticeInstitution
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Metabolomic Unit pays non établi dans la noticeInstitution
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Department of Biosciences pays non établi dans la noticeInstitution
Istituto Neurologico Mediterraneo, Università Cattolica del Sacro Cuore et Azienda USL di Bologna, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.