Domains of prognostic awareness, quality of life, and psychological distress in patients with advanced cancer
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Le résumé fourni par la source
INTRODUCTION: Prior studies have shown mixed findings regarding the relationship between prognostic awareness with quality of life (QOL) and psychological distress in patients with advanced cancer. Prognostic awareness is a multidimensional construct including a cognitive component (ie, the ability to understand one's life-limiting illness) and an emotional coping component (ie, the capacity to process terminal prognosis). Yet, it remains unclear which domains of prognostic awareness are associated with QOL and psychological distress. MATERIALS AND METHODS: We conducted a cross-sectional study of adults with metastatic solid tumors treated with noncurative intent at a single academic center from 11/2019 to 6/2022. We used the Prognostic Awareness Impact Scale (PAIS) to measure components of prognostic awareness, including the cognitive and emotional coping components. We used the Functional Assessment of Cancer Therapy-G and Hospital Anxiety and Depression Scale to measure QOL and psychological distress, respectively. Linear regression models were used to examine the relationship between the PAIS domains and patient-reported outcomes. RESULTS: We enrolled 61.9% (632/1021) of eligible patients. Cognitive understanding of prognosis was not associated with QOL (B = -2.3, P = .114), anxiety (B = 0.7, P = .057), or depression symptoms (B = 0.4, P = .293). However, higher emotional coping with prognosis was associated with better QOL (B = 1.7; P < .001), lower anxiety (B = -0.6; P < .001), and depression (B = -0.3; P < .001). CONCLUSION: Patients' emotional coping with their prognosis, rather than cognitive acknowledgment of their incurable cancer, was associated with QOL and psychological distress. Our findings underscore patients' ability to tolerate an accurate understanding of their prognosis and the critical need to incorporate effective coping strategies during prognostic discussions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Domains of prognostic awareness, quality of life, and psychological distress in patients with advanced cancer
- Date Crossref
- 10/10/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Brigham and Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Harvard University Harvard Medical School pays non établi dans la noticeUniversité ou école supérieure
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Dana-Farber Cancer Institute pays non établi dans la noticeStructure de recherche
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University of Miami pays non établi dans la noticeUniversité ou école supérieure
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Brown University pays non établi dans la noticeUniversité ou école supérieure
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University of Massachusetts Chan Medical School pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital pays non établi dans la noticeÉtablissement de santé
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Palo Alto University pays non établi dans la noticeUniversité ou école supérieure
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Stanford University pays non établi dans la noticeUniversité ou école supérieure
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Harvard Medical School pays non établi dans la noticeInstitution
Brigham and Women's Hospital, Harvard Medical School — Harvard University et Dana-Farber Cancer Institute, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.