Synergistic Micellization and Vesicle Formation in Bile Salts and Dihexadecyldimethylammonium Bromide Mixed Systems
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Le résumé fourni par la source
The design of tunable self-assembly systems is increasingly important for the development of advanced nanostructures in biomedical applications. Single-surfactant assemblies often suffer from limited stability and adaptability, whereas mixed surfactant systems, particularly those combining biologically relevant bile salts with double-tailed cationic surfactants, offer enhanced physicochemical properties. However, comprehensive experimental investigations into their micellar interactions, thermodynamic stability, and aggregation morphologies remain limited. In this study, the self-assembly behavior of sodium cholate (NaC) and sodium deoxycholate (NaDC) with dihexadecyldimethylammonium bromide (DHDAB) in aqueous solution was systematically examined. Surface tension and conductivity measurements across varying mole fractions were analyzed using the Clint, Rubingh, and Rosen models to determine the critical micelle concentration (CMC), surface excess concentration (Γ max ), minimum molecular area (A min ), and interaction parameters (β m, β o ), along with the thermodynamic characteristics of micellization. Negative interaction parameter values and consistently low CMCs across all compositions confirmed strong synergistic interactions between the amphiphilic constituents. The thermodynamic stability of micellization is governed by electrostatic complementarity, hydrophobic chain disparity, intermolecular hydrocarbon interactions, and ion–dipole forces. Complementary structural analyses using dynamic light scattering (DLS), small-angle neutron scattering (SANS), and transmission electron microscopy (TEM) revealed the formation of vesicular micelles, consistent with predictions of the packing parameter and cooperative self-assembly. Thermodynamic analyses further confirmed that micellization is spontaneous and predominantly driven by entropy. Overall, these findings demonstrate that bile salt–cationic surfactant mixtures can generate stable and tunable vesicular assemblies, providing a molecular framework for nanocarrier development, controlled drug release, and sustainable material formulations, while emphasizing the need for further studies on their biocompatibility and functionalization for targeted delivery.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synergistic Micellization and Vesicle Formation in Bile Salts and Dihexadecyldimethylammonium Bromide Mixed Systems
- Date Crossref
- 10/10/2025
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Veer Narmad South Gujarat University pays non établi dans la noticeUniversité ou école supérieure
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Sardar Vallabhbhai National Institute of Technology Surat pays non établi dans la noticeUniversité ou école supérieure
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Bhabha Atomic Research Centre pays non établi dans la noticeStructure de recherche
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Solid State Physics Laboratory pays non établi dans la noticeStructure de recherche
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Department of Chemistry pays non établi dans la noticeInstitution
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Navyug Science College pays non établi dans la noticeUniversité ou école supérieure
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Chemical Division pays non établi dans la noticeInstitution
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Department of Chemical Engineering pays non établi dans la noticeInstitution
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Solid State Physics Division pays non établi dans la noticeInstitution
Veer Narmad South Gujarat University, Sardar Vallabhbhai National Institute of Technology Surat et Bhabha Atomic Research Centre, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.