Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS
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Le résumé fourni par la source
OBJECTIVE: This study aims to investigate alterations in glymphatic system (GS) function in patients with non-alcoholic fatty liver disease (NAFLD) and explore the relationship of these alterations with cognition and clinical indicators. MATERIALS AND METHODS: In this cross-sectional study, forty-three patients with pre-cirrhotic NAFLD (male: 37, mean age: 38.2 ± 6.7 years) and twenty-three age-, sex-, and education-matched controls (male: 17, mean age: 41.0 ± 6.7 years) underwent diffusion tensor imaging (DTI) examination and cognitive measurements. The DTI analysis along the perivascular space (DTI-ALPS) index, calculated from the DTI data, assessed differences in GS function between the two groups. Linear regression analysis examined the relationship between the ALPS index and Z-transformed cognitive scores. Spearman/Pearson correlation analysis was conducted for assessing the relationship of the ALPS index with clinical indicators. RESULTS: After adjusted for age, sex, and BMI, NAFLD patients exhibited significantly lower ALPS index and higher diffusivity of projection fibers in the direction of the y-axis than controls (both P < 0.001). In the NAFLD group, the ALPS index was significantly correlated with the Mini-Mental State Examination score (beta [95% CI] = 2.123 [0.156, 4.091], P = 0.035) and the clock drawing score (beta [95% CI] = 4.233 [0.073, 8.393], P = 0.046) after adjusting for age, sex, body mass index, and education level. In addition, there was a significantly positive correlation between the ALPS index and abdominal visceral adipose tissue area (r = 0.353, P = 0.020) after adjusting for age, sex, and BMI in NAFLD patients. CONCLUSION: NAFLD patients without cirrhosis showed significantly a reduced ALPS index compare to matched controls, indicating potential alterations in GS function. These alterations correlated with cognitive performance and clinical indicators, implying a possible link between GS function and cognitive performance in NAFLD that requires longitudinal validation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS
- Date Crossref
- 10/10/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wenzhou Medical University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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Wenzhou Institute of Technology Testing & Calibration pays non établi dans la noticeInstitution
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Philips (China) pays non établi dans la noticeEntreprise
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Wenzhou University pays non établi dans la noticeUniversité ou école supérieure
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Wenzhou Key Laboratory of Structural and Functional Imaging pays non établi dans la noticeStructure de recherche
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Philips Healthcare pays non établi dans la noticeInstitution
Department of Radiology — Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University et Wenzhou Institute of Technology Testing & Calibration, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.