A Comparative Analysis of Diagnostic Performance and Cytomorphologic Features Between Newly Developed WellPrep® and SurePath™ in Serous Effusion Cytology
Rattachement africain : kr, cy. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Introduction: Whereas liquid-based cytology (LBC) is often the preferred method in gynecological and non-gynecological cytopathology compared to conventional preparation, it does have several limitations. This study aims to evaluate the diagnostic accuracy and specific cytomorphologic characteristics of the newly developed WellPrep ® (WP) in comparison with SurePath™ (SP) in serous effusion cytology. Materials and Methods: A total of 178 body cavity effusion samples were collected, which were divided and further processed using both WP and SP methods. The LBC slides of the cases were independently evaluated regarding their cytomorphologic features by three pathologists. Among them, the diagnosis of 66 cases (42.6%) was confirmed as non-neoplastic or malignant using a combination of histopathological, clinical, and/or radiological follow-up. Statistical analysis was conducted to assess the diagnostic concordance and differences in selected cytomorphologic features between the two LBC methods. Results: WP demonstrated diagnostic performance comparable to SP, with a concordance rate of 75.7% (kappa = 0.659; Spearman’s ρ = 0.920). Furthermore, the diagnostic accuracy measures tested were not different between WP and SP. No case processed with WP or SP showed suboptimal slide quality. For cytomorphologic features, cellular degeneration was less frequently observed in WP than in SP. SP showed more even cellular distribution and better preservation of architectural patterns. SP also more frequently exhibited prominent nucleoli, cytoplasmic vacuoles, and signet ring cell features. Conclusion: WP offers comparable slide quality and diagnostic accuracy with SP in serous effusion cytopathology. However, more research using larger patient cohorts would provide more evidence regarding WP.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Comparative Analysis of Diagnostic Performance and Cytomorphologic Features Between Newly Developed WellPrep® and SurePath™ in Serous Effusion Cytology
- Date Crossref
- 01/07/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bristol-Myers Squibb (South Korea) pays non établi dans la noticeEntreprise
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The Catholic University of Korea Bucheon St. Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Catholic University of Korea pays non établi dans la noticeUniversité ou école supérieure
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Seoul National University Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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University of Cyprus Medical School pays non établi dans la noticeUniversité ou école supérieure
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Seoul National University Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Pathology pays non établi dans la noticeInstitution
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College of Medicine Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
Bristol-Myers Squibb (South Korea), The Catholic University of Korea Bucheon St. Mary's Hospital et Catholic University of Korea, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.