Influence of Pre‐Vaccination HPV Status on Vaccine Effectiveness Among Chinese Women: A Multicenter Cross‐Sectional Study
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Le résumé fourni par la source
BACKGROUND AND AIMS: Human papillomavirus (HPV) vaccines have been available in China for only 8 years, and routine HPV testing is not recommended prior to vaccination. Therefore, evaluation of HPV vaccine effectiveness and the impact of pre-vaccination HPV infection status on vaccine protective effect in Chinese women is warranted. METHODS: From June 2022 to June 2023, women aged 18 to 50 years without a history of cervical or uterine excision were recruited from three medical institutions. Baseline characteristics were compared between vaccinated and unvaccinated participants, with inverse probability treatment weighting (IPTW) applied to adjust for confounding factors. HPV infection rates and vaccine effectiveness (VE) were calculated. Additionally, a sub-group analysis was conducted among vaccinated women to explore the impact of pre-vaccination HPV infection status. RESULTS: After adjusting for group differences, the vaccine effectiveness against new HPV16/18 infections was 76.1% (95% CI: 58.7%-86.2%) among 2285 participants. Older age and possession of a master's degree or higher were identified as protective factors, whereas increased parity and exclusive use of oral contraceptives were determined to be risk factors for HPV16/18 infection. Women with unknown pre-vaccination HPV status exhibited significantly higher post-vaccination rates of high-risk HPV infections (RR 4.278, 95% CI: 2.537-7.215) compared to those who were HPV-negative prior to vaccination. However, no significant difference in new high-risk HPV infection rates was observed between pre-vaccination HPV-negative and HPV-positive women. CONCLUSION: In addition to HPV vaccination, factors such as age, parity, exclusive use of oral contraceptives, and higher education attainment were independently associated with HPV16/18 infection rates. Pre-vaccination HPV infection status did not significantly influence the protective efficacy of the HPV vaccine against previously unencountered HPV types.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Influence of Pre‐Vaccination <scp>HPV</scp> Status on Vaccine Effectiveness Among Chinese Women: A Multicenter Cross‐Sectional Study
- Date Crossref
- 28/08/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Central South University Department of Gynecology Xiangya Hospital pays non établi dans la noticeUniversité ou école supérieure
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Xiangya Hospital Central South University pays non établi dans la noticeÉtablissement de santé
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Changsha Hospital for Maternal and Child Health Care pays non établi dans la noticeÉtablissement de santé
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Liuzhou Maternal and Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Peking University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Peking University People's Hospital pays non établi dans la noticeÉtablissement de santé
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Fujian Medical University pays non établi dans la noticeUniversité ou école supérieure
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Fuzhou Maternity and Child Health Care Hospital pays non établi dans la noticeÉtablissement de santé
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Gynecological Oncology Research and Engineering Center of Hunan Province Changsha China pays non établi dans la noticeInstitution
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Affiliated to Hunan Normal University Changsha China Department of Obstetrics & pays non établi dans la noticeUniversité ou école supérieure
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Department of Gynecology Liling Maternal and Child Health Care Hospital Zhuzhou Hunan China Department of Gynecology pays non établi dans la noticeÉtablissement de santé
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Department of Gynecology College of Clinical Medicine for Obstetrics & Laboratory of Gynecologic Oncology pays non établi dans la noticeUniversité ou école supérieure
Department of Gynecology Xiangya Hospital — Central South University, Xiangya Hospital Central South University et Changsha Hospital for Maternal and Child Health Care, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.