Clinical Presentation of Chronic Myeloid Leukaemia and Its Correlation with Haematological Parameters in Kenya
Rattachement africain : Kenya, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Chronic myeloid leukaemia (CML) is commonly asymptomatic and is discovered incidentally in up to about 50% of patients in chronic phase, due to abnormally high white blood cell (WBC) counts. Commonest symptoms include fatigue and abdominal pain/discomfort, while some patients present with bleeding tendencies. Unusual manifestations include hearing and visual loss. Methods: This was a retrospective analysis of data from patients attending the Glivec International Patient Assistance Clinic at the Nairobi Hospital between January 2006 and December 2018. In-formation sourced included demographic profiles, findings on physical examination, and laboratory values. Absolute, range, median and mean counts for white blood cells (WBC ×109/l), ab-solute neutrophil count (ANC×109/l), platelets (PLT ×109/l), haemoglobin (hgb, g/dl), BCR:ABL1 baseline levels, and bone marrow blast percentage at diagnosis. All parameters were tested against each of the clinical presentations. Results: We enrolled 583 patients; the mean age was 39.8 years. The commonest symptom was abdominal swelling in 235 cases (40.3%); 70 (12%) experienced abdominal pain. Priapism occurred in 4 males (0.69%), blindness and deafness in 8 patients (1.37%). Splenomegaly was significantly more common among males than females (P = 0.015). Patients aged ≤ 20 years were more likely to be in heart failure (P = 0.032); leg swelling was more in those with high platelet counts (p=0.023). Unclear presentations were more common in those with high WBC counts (p=0.015). Total WBC counts and BCR:ABL1 levels were higher among younger patients (p=0.036, and 0.025, respectively). Patients with leg swelling had lower BCR:ABL1 levels (p=0.005), those in heart failure had significantly higher BCR:ABL1 levels at baseline compared with the rest (p=0.037). Patients with lymphadenopathy were more likely to have lower ANCs (p=0.035). Patients who had pallor had a significantly lower BCR:ABL1 values compared with those without (P = 0.025). Similarly, patients who had leg swelling had a significantly lower mean BCR:ABL1 percentage compared with those without (P = 0.005). In contrast, those in heart failure had significantly higher mean BCR:ABL1 values (P = 0.037). Those with lymphadenopathy had significantly lower absolute neutrophil counts compared with those without (P =0.035). Conclusions: Clinical manifestations of CML cannot be explained merely by haematologic values. Complex biologic and physico-chemical factors should be further interrogated.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Presentation of Chronic Myeloid Leukaemia and Its Correlation with Haematological Parameters in Kenya
- Date Crossref
- 02/07/2025
- Éditeur
- Eterno Press Sdn. Bhd.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nairobi Hospital Nairobi Hospital, Kenya (code pays fourni par la source)Établissement de santé
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Kenyatta University P.O Box 43844-00100 Nairobi, Kenya (code pays fourni par la source)Université ou école supérieure
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University of Nairobi University of Nairobi, Kenya (code pays fourni par la source)Université ou école supérieure
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Kenyatta National Hospital Cancer Treatment Centre Nairobi, Kenya (code pays fourni par la source)Établissement de santé
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Kenya Medical Research Institute Kenya (code pays fourni par la source)Structure de recherche
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Azienda USL di Bologna pays non établi dans la noticeÉtablissement de santé
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University of Bologna Department of Medical and Surgical Sciences (DIMEC) pays non établi dans la noticeUniversité ou école supérieure
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Novartis Global Health Nairobi, Kenya (pays nommé en fin d’affiliation)Institution
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School of Biological Sciences Kenya Medical Research Institute University of Nairobi, Kenya (pays nommé en fin d’affiliation)Université ou école supérieure
Nairobi Hospital (Nairobi Hospital, Kenya), Kenyatta University (P.O Box 43844-00100 Nairobi, Kenya) et University of Nairobi (University of Nairobi, Kenya), avec 6 autres affiliations. Pays d’affiliation : Kenya.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.