Clinical outcomes and prognostic factors of adjuvant radiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
This study aimed to analyze the clinical outcomes and prognostic factors of postoperative adjuvant radiotherapy (RT) for vulvar cancer based on a retrospective Japanese nationwide survey. Data were collected from 108 institutions for patients diagnosed with vulvar cancer between January 2001 and December 2010. Patients with histologically confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma who underwent curative surgery and adjuvant radiotherapy were included in this study. Survival outcomes were estimated using the Kaplan-Meier method, and prognostic factors were analyzed via univariate and multivariate models. A total of 139 patients were included, with a median follow-up of 44 months (range: 3-169). The 5-year overall survival (OS) rates (95% confidence interval [CI]) for stages I, II, III, and IV were 71.8% (50.8-92.8%), 61.3% (40.1-82.5%), 58.0% (45.8-70.2%), and 47.3% (27.5-67.1%), respectively. The corresponding 5-year cause-specific survival (CSS) rates (95% CI) for stages I, II, III, and IV were 71.8% (50.8-92.8%), 73.4% (53.0-93.8%), 62.2% (50.0-74.4%), and 47.3% (27.5-67.1%). Multivariate analysis identified age ≥70 years as an independent adverse prognostic factor for OS (hazard ratio [HR]: 1.848; 95% CI: 1.039-3.281; P = 0.042), while the presence of ≥2 inguinofemoral lymph node metastases was significantly associated with poorer CSS (HR: 2.179; 95% CI: 1.109-4.280; P = 0.030). Our analysis identified advanced age and a higher nodal burden as significant predictors of poorer survival outcomes in patients with vulvar cancer receiving postoperative adjuvant RT.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical outcomes and prognostic factors of adjuvant radiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study
- Date Crossref
- 27/08/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Kanagawa Prefectural Hospital Organization pays non établi dans la noticeÉtablissement de santé
-
Kanagawa Cancer Center pays non établi dans la noticeÉtablissement de santé
-
Gunma University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
-
Juntendo University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
-
University of Tokyo Hospital pays non établi dans la noticeÉtablissement de santé
-
The University of Tokyo Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Tokushima University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Mie University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Yamaguchi University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Shizuoka Cancer Center pays non établi dans la noticeOrganisme public
-
Jikei University School of Medicine Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
-
Kurume University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
Kanagawa Prefectural Hospital Organization, Kanagawa Cancer Center et Department of Radiation Oncology — Gunma University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.