Impaired Treg‐Mediated Immune Regulation in Peri‐Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses
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Le résumé fourni par la source
AIM: To evaluate the T regulatory lymphocyte (Treg) profile and its potential contribution to peri-implant tissue destruction during peri-implantitis (PI). METHODS: PI granulation tissue and crevicular fluid collected during PI surgical (PI group, n = 23) and explantation (PI-X group, n = 23) therapy, with peri-implant healthy tissue from second-stage surgery (H group, n = 20) as controls, were analysed. The inflammatory infiltrate was characterised by H&E staining. The relative expression of Treg-associated transcription factors and cytokines was assessed by RT-qPCR. Forkhead box P3 (FOXP3) and neuropilin (NPR)-1 were detected by immunohistochemistry, and interleukin (IL)-10, TGF-β1 and IL-35 by ELISA. The clinical parameters, namely probing depth (PD), bleeding on probing (BOP) and vertical defect depth (VDD), were also recorded. RESULTS: area were detected in PI and PI-X lesions (p < 0.05). IL-35 levels were up-regulated, whereas TGF-β1 levels were down-regulated in PI and PI-X lesions, compared to H samples (p < 0.05). PD and VDD were significantly correlated with the down-regulation of FOXP3 and NRP-1 (p < 0.05). CONCLUSIONS: Treg dysfunction and altered cytokine profiles in PI are associated with inflammation and clinical disease severity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impaired Treg‐Mediated Immune Regulation in Peri‐Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses
- Date Crossref
- 26/08/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Goethe University Frankfurt Department of Oral Surgery and Implantology pays non établi dans la noticeUniversité ou école supérieure
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Universidad Científica del Sur Oral Peri‐Implant Research Group pays non établi dans la noticeUniversité ou école supérieure
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University of Bern Department of Oral Surgery and Stomatology pays non établi dans la noticeUniversité ou école supérieure
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School of Dental Medicine Department of Oral Surgery and Stomatology pays non établi dans la noticeUniversité ou école supérieure
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Medical Center of the Johann Wolfgang Goethe University Department for Oral pays non établi dans la noticeUniversité ou école supérieure
Department of Oral Surgery and Implantology — Goethe University Frankfurt, Oral Peri‐Implant Research Group — Universidad Científica del Sur et Department of Oral Surgery and Stomatology — University of Bern, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.