Incidence of and Determinants for Substance Use Disorders Among Individuals With Long‐Term Prescription Opioid Use: A Population‐Based Cohort Study
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Le résumé fourni par la source
PURPOSE: To assess the incidence of substance use disorders (SUDs) after long-term prescription opioid use (LTOU) and to identify socioeconomic and clinical risk factors associated with SUD among individuals with LTOU. METHODS: Cohort study using linked nationwide registers (2011-2019). We identified 114 916 individuals who used opioids for more than 3 months (LTOU) without previous LTOU or SUD diagnosis. Outcomes were any incident SUD diagnosed in primary or secondary care (ICPC-2: P15-P16, P18-P19; ICD-10: F10-F16, F18-F19) and opioid use-related disorders (OUD) diagnosed in secondary care (ICD-10: F11). We calculated age- and sex-stratified incidence rates (IR), incidence rate ratios (IRR) and age-standardized incidence rates (ASIR). Adjusted hazard ratios (aHR) were calculated using Cox proportional hazards regression. RESULTS: In total, 5.3% (6069/114916) were diagnosed with SUD (ASIR = 28.7 per 1000 person-years), and males had higher IRs compared to females (IRR). Males had higher risk of SUD in both the younger (aHR = 1.59, 95% CI 1.47-1.72) and older (1.66, 1.54-1.78) age group. Low education (1.87, 1.66-2.11) and unemployment (1.26, 1.15-1.38) had the strongest association with SUD in the younger age group versus low income (1.37, 1.21-1.57) and living alone (1.53, 1.41-1.65) in the older age group. Previously diagnosed mental disorders and use of benzodiazepines- or benzodiazepine-related drugs (BZDRs) were associated with SUD in both age groups (1.85, 1.71-2.01; 2.37, 2.18-2.57). Being male and having used BZDRs were the covariates strongest associated with OUD. CONCLUSIONS: Being male, young, having low socioeconomic status, previous mental disorders or BZDR use were associated with SUD diagnosis among individuals with LTOU.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Incidence of and Determinants for Substance Use Disorders Among Individuals With Long‐Term Prescription Opioid Use: A Population‐Based Cohort Study
- Date Crossref
- 25/08/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Oslo Norwegian Centre for Addiction Research (SERAF) pays non établi dans la noticeUniversité ou école supérieure
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Stavanger University Hospital Center for Alcohol and Drug Research (KORFOR) pays non établi dans la noticeÉtablissement de santé
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University of Stavanger Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Niuvanniemi Hospital Department of Forensic Psychiatry pays non établi dans la noticeÉtablissement de santé
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Norwegian Institute of Public Health Department of Chronic Diseases pays non établi dans la noticeOrganisme public
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Faculty of Health Sciences Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
Norwegian Centre for Addiction Research (SERAF) — University of Oslo, Center for Alcohol and Drug Research (KORFOR) — Stavanger University Hospital et Department of Public Health — University of Stavanger, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.