Paramagnetic rim lesions are associated with choroid plexus inflammation and expansion over 5 years in people with multiple sclerosis
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Le résumé fourni par la source
BACKGROUND: Chronic active white matter inflammation is linked with multiple sclerosis (MS) clinical severity and is likely integral in MS progression. It has also been associated with choroid plexus (CP) inflammation in vivo, pointing to a potential pathophysiological link between the two phenomena. However, how these aspects of the disease co-evolve over time remains poorly understood nor has their relationship been specifically assessed in people with progressive MS (pwPMS). METHODS: In this retrospective analysis of a longitudinal study, 129 people with MS (pwMS; 86 people with relapsing remitting (pwRRMS) and 43 pwPMS) were imaged with 3 T MRI at baseline and after 5.4 years of follow-up. CP volume and CP pseudo-T2 (pT2) were calculated as measures reflecting CP inflammation in MS. Paramagnetic rim lesions (PRLs), a marker of chronic active white matter inflammation, were assessed at baseline for the whole cohort, and longitudinally in 96 pwMS with available data (66 pwRRMS, 32 pwPMS). Baseline and longitudinal associations between the CP and PRLs, including interactions with disease course, were assessed, adjusted for covariates including age and sex. RESULTS: PwMS with PRLs had significantly larger CP volume at baseline than pwMS without PRLs after correcting for age, sex, and disease duration (mean difference: 0.3 ± 1.2 mL; p = 0.042). Longitudinally, baseline PRL number was associated with increased CP volume in pwPMS (B = 0.22 mL/mL; p < 0.001), but not people with relapsing-remitting MS (B = - 0.01 mL/mL; p > 0.7). CONCLUSION: Increased CP volume is related to chronic white matter inflammation, particularly in pwPMS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Paramagnetic rim lesions are associated with choroid plexus inflammation and expansion over 5 years in people with multiple sclerosis
- Date Crossref
- 21/08/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jacobs Institute pays non établi dans la noticeOrganisation à but non lucratif
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University at Buffalo Center for Biomedical Imaging at the Clinical Translational Science Institute pays non établi dans la noticeUniversité ou école supérieure
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Strong Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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Buffalo Psychiatric Center pays non établi dans la noticeStructure de recherche
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Jacobs School of Medicine and Biomedical Sciences Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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University of Rochester Department of Imaging Sciences pays non établi dans la noticeUniversité ou école supérieure
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Jacobs Neurological Institute pays non établi dans la noticeStructure de recherche
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IRCCS Mondino Foundation Multiple Sclerosis Centre pays non établi dans la noticeOrganisation à but non lucratif
Jacobs Institute, Center for Biomedical Imaging at the Clinical Translational Science Institute — University at Buffalo et Strong Memorial Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.