Association of volatile organic compounds with serum lactate dehydrogenase levels in the general adults
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Le résumé fourni par la source
OBJECTIVES: This study aimed to investigate the associations between urinary metabolites of Volatile organic compounds (mVOCs) and serum Lactate dehydrogenase (LDH) levels in a representative sample of the U.S. adults. METHODS: We analyzed data from 4907 participants in NHANES 2011-2018. Seventeen urinary mVOCs were measured, and serum LDH was used as the outcome. Generalized linear models (GLM), restricted cubic splines (RCS), and weighted quantile sum (WQS) regression were used to assess linear, nonlinear, and mixture effects. Sensitivity analyses were conducted using urinary creatinine-corrected mVOC concentrations, and quantile g-computation (qgcomp) was applied as an alternative mixture modeling approach to validate the robustness of our findings. Furthermore, false discovery rate (FDR) correction was applied to account for multiple comparisons. RESULTS: Several mVOCs were significantly associated with serum LDH. Notably, 2MHA, 34MHA, ATCA, and CYMA showed robust inverse associations, while PHEM was positively associated with LDH. RCS models revealed non-linear exposure-response relationships for multiple mVOCs. WQS regression indicated that both positively and negatively weighted mVOCs contributed to LDH levels, with DHBMA as a major positive contributor and 34MHA as a negative contributor. Most associations remained stable after sensitivity analyses. CONCLUSIONS: This study demonstrates that urinary mVOCs are associated with serum LDH levels, suggesting potential subclinical toxic effects of VOC exposure. These findings underscore the need for environmental risk management and further investigation into the biological pathways linking VOCs to systemic health outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of volatile organic compounds with serum lactate dehydrogenase levels in the general adults
- Date Crossref
- 15/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sun Yat-sen University Guangdong Engineering Technology Research Center of Nutrition Transformation pays non établi dans la noticeUniversité ou école supérieure
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Hangzhou Normal University pays non établi dans la noticeUniversité ou école supérieure
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Shenzhen Nanshan Center for Chronic Disease Control pays non établi dans la noticeÉtablissement de santé
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School of Public Health (Shenzhen) Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Nanshan Mental Health Center Shenzhen Nanshan Center for Chronic Disease Control and Shenzhen pays non établi dans la noticeÉtablissement de santé
Guangdong Engineering Technology Research Center of Nutrition Transformation — Sun Yat-sen University, Karolinska Institutet et Hangzhou Normal University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.