Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn’s Disease
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Le résumé fourni par la source
BACKGROUND & AIMS: Preoperative body composition is a potential modifiable risk factor for poor postoperative outcomes in Crohn's disease (CD). This study aimed to investigate the association of preoperative body composition parameters with postoperative complications and endoscopic postoperative recurrence (ePOR) in patients with CD following ileocolic (re-)resection (ICR). METHODS: Patients with CD (≥16 years) scheduled for ICR with preoperative abdominal imaging (<12 months) (n = 227) were identified from a prospective, multicenter cohort study. Cross-sectional surface area normalized for body height (ie, index) and lipid content in sketelal muscle mass (SM) and subcutaneous and visceral adipose tissue (SAT/VAT) were analyzed on imaging. Associations with postoperative complications (Clavien-Dindo I-IV), moderate-to-severe complications (Clavien-Dindo ≥II), infectious complications, and ePOR (modified Rutgeerts' score ≥i2b) were explored. RESULTS: High lipid content in SM (ie, myosteatosis) was associated with overall postoperative (adjusted odds ratio [aOR], 3.09; 95% confidence interval [CI], 1.36-7.00), moderate-to-severe (aOR, 2.66; 95% CI, 1.24-5.68), and infectious complications (aOR, 2.44; 95% CI, 1.10-5.40). Low preoperative SAT index was protective against postoperative complications (aOR, 0.38; 95% CI, 0.16-0.88). Low lipid content in VAT was associated with postoperative infectious complications (aOR, 4.31; 95% CI, 1.11-16.71), whereas high lipid content in VAT was protective against ePOR (aOR, 0.26; 95% CI, 0.07-0.99). Both low (aOR, 4.46; 95% CI, 1.09-19.57) and high SM index were associated with ePOR (aOR, 2.45; 95% CI, 1.06-5.65). CONCLUSIONS: Preoperative myosteatosis was consistently associated with overall postoperative complications, moderate-to severe, and infectious complications, in patients with CD following ICR. Furthermore, several body composition parameters were identified as risk factor or protective factor for postoperative complications and ePOR. Inconsistent findings were observed for SM levels and ePOR risk. The correlation between improvements of these parameters and postoperative outcomes requires further study.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn’s Disease
- Date Crossref
- 01/05/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Maastricht University Medical Centre Institute of Nutrition and Translational Research in Metabolism (NUTRIM) pays non établi dans la noticeOrganisme public
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Maastricht University Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Flevoziekenhuis pays non établi dans la noticeÉtablissement de santé
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Zuyderland Medisch Centrum pays non établi dans la noticeÉtablissement de santé
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University Medical Center Groningen Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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University of Groningen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeOrganisme public
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Medisch Centrum Haaglanden pays non établi dans la noticeÉtablissement de santé
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Leiden University Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeOrganisme public
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Amsterdam University Medical Centers Department of Surgery pays non établi dans la noticeÉtablissement de santé
Erasmus MC, Institute of Nutrition and Translational Research in Metabolism (NUTRIM) — Maastricht University Medical Centre et Department of Surgery — Maastricht University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.