Xiao‐Jie‐An Capsule Alleviates Uterine Fibroids by Modulating Oestrogen–Progesterone Balance and Reducing Inflammatory Response
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Le résumé fourni par la source
Uterine fibroids (UF) are benign tumours composed of smooth muscle cells and fibrous connective tissue. UF are common among women aged 30-50 years and often present with symptoms such as anaemia, pelvic pain and bladder dysfunction. Xiao-Jie-An Capsule (XJA), a traditional Chinese medicine formula, has been clinically used to treat UF. However, the underlying mechanisms of its efficacy remain unclear. The aim of this study was to determine the therapeutic effect of XJA and related mechanisms in a UF rat model. The experimental results showed that XJA significantly alleviated abnormalities in uterine morphology, tissue structure and purulent discharge in the UF rats. XJA also reduced serum oestrogen and progesterone in UF rats. Moreover, XJA decreased blood pro-inflammatory factors in UF rats by modulating the TLR4/NF-κB pathway. Western blotting and immunohistochemistry analyses revealed that XJA decreased the expression of Bcl-2, PCNA and Ki67 while increasing the expression of Bax, indicating its role in inhibiting cell proliferation and promoting apoptosis. Additionally, XJA exhibited immunomodulation in UF rats. In summary, our study suggests that XJA alleviates UF by multiple targets and mechanisms, such as restoring the oestrogen-progesterone balance, reducing inflammation, inhibiting cell proliferation, inducing apoptosis and regulating immune function.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Xiao‐Jie‐An Capsule Alleviates Uterine Fibroids by Modulating Oestrogen–Progesterone Balance and Reducing Inflammatory Response
- Date Crossref
- 28/07/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Peking University State Key Laboratory of Vascular Homeostasis and Remodeling pays non établi dans la noticeUniversité ou école supérieure
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Taizhou University pays non établi dans la noticeUniversité ou école supérieure
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Northwest University Xi'an People's Hospital (Xi'an Fourth Hospital) pays non établi dans la noticeUniversité ou école supérieure
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Shaanxi Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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School of Basic Medical Sciences State Key Laboratory of Vascular Homeostasis and Remodeling pays non établi dans la noticeUniversité ou école supérieure
State Key Laboratory of Vascular Homeostasis and Remodeling — Peking University, Taizhou University et Xi'an People's Hospital (Xi'an Fourth Hospital) — Northwest University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.