Characterisation of the Faecal Microbiota in Dogs with Mast Cell Tumours Compared with Healthy Dogs
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Le résumé fourni par la source
Mast cell tumours (MCT) are the most common cutaneous neoplasms in dogs, with variable behaviours and patient survival time. Both indolent and aggressive forms have been described, but much remains to be explored regarding prognosis and therapy. Evidence has highlighted the influence of microbiota on multiple health and disease processes, including certain types of cancer in humans. However, knowledge remains scarce regarding microbiota biology and its interactions in both humans and canine cancer patients. This study aimed to characterise the faecal microbiota of dogs with MCT and compare it with that of healthy individuals. Twenty-eight dogs diagnosed with MCT and twenty-eight healthy dogs were enrolled in the study. Faecal samples were collected and analysed by Illumina sequencing of 16S rRNA genes. Alpha diversity was significantly lower in dogs with cancer, and the species diversity InvSimpson Indexwas reduced (p = 0.019). Principal coordinate analysis showed significant differences in the bacterial profile of the two groups: there was a significant lower abundance of the genera Alloprevotella, Holdemanella, Erysipelotrichaceae_UCG-003, and Anaerobiospirillum and, conversely, a significant increase in the genera Escherichia-Shigella and Clostridium sensu stricto 1 in diseased dogs. At the phylum level, Bacteroidota was significantly reduced in diseased dogs (25% in controls vs. 19% in MCT dogs). In conclusion, sequencing analysis provided an overview of the bacterial profile and showed statistical differences in the microbial communities of dogs with MCT compared with healthy dogs, suggesting a link between the gut microbiota and MCT in this species.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characterisation of the Faecal Microbiota in Dogs with Mast Cell Tumours Compared with Healthy Dogs
- Date Crossref
- 27/07/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade do Porto pays non établi dans la noticeUniversité ou école supérieure
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Cooperativa de Ensino Superior Politécnico e Universitário pays non établi dans la noticeUniversité ou école supérieure
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University of Trás-os-Montes and Alto Douro Animal and Veterinary Research Centre (CECAV) pays non établi dans la noticeUniversité ou école supérieure
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Hospital Veterinário do Porto (Portugal) pays non établi dans la noticeEntreprise
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Animal Science and Study Centre (CECA) 4050-313 Porto pays non établi dans la noticeInstitution
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University of Porto Department of Veterinary Clinics pays non établi dans la noticeUniversité ou école supérieure
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Interdisciplinary Centre of Marine and Environmental Research (CIMAR/CIIMAR) pays non établi dans la noticeInstitution
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Anicura CHV—Veterinary Hospital Center pays non établi dans la noticeÉtablissement de santé
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University Institute of Health Sciences Animal and Veterinary Department pays non établi dans la noticeUniversité ou école supérieure
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Onevetgroup Hospital Veterinário do Porto (HVP) pays non établi dans la noticeÉtablissement de santé
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Faculty of Sciences (FCUP) Department of Biology pays non établi dans la noticeUniversité ou école supérieure
Universidade do Porto, Cooperativa de Ensino Superior Politécnico e Universitário et Animal and Veterinary Research Centre (CECAV) — University of Trás-os-Montes and Alto Douro, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.