Low‐dose versus high‐dose methylprednisolone for children with severe Mycoplasma pneumoniae pneumonia (MCMP): A randomized controlled trial
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Le résumé fourni par la source
Importance: pneumonia (MPP), evidence regarding glucocorticoid dose is lacking. Objective: To evaluate the effects of low- and high-dose methylprednisolone on the risk of long-term pulmonary lesions for children with severe MPP when combined with azithromycin. Methods: This randomized, parallel-controlled, multicenter clinical trial was conducted in mainland China and enrolled pediatric patients hospitalized with severe MPP. A total of 424 enrolled patients were randomized (allocation ratio of 1:1) to azithromycin combined with either a low-dose [2 mg/(kg·d)] or a high-dose [10 mg/(kg·d)] methylprednisolone treatment for 3 d followed by tapering over 12 d. The primary outcome was the incidence of composite adverse outcomes, including atelectasis, bronchiectasis, or bronchiolitis obliterans 6 months after treatment. Results: A total of 118 (27.8%) developed adverse pulmonary lesions at 6 months after treatment; 66 of 211 (31.3%) in the high-dose methylprednisolone group and 52 of 213 (24.4%) in the low-dose group, respectively. The risk ratio of long-term pulmonary lesions in a high-dose group to those in a low-dose group was 1.28 (95% confidence interval [95% CI]: 0.94-1.75). In addition, the risk of hypertension in the high-dose group (8.1%, 17 of 211) was higher than that in the low-dose group (1.4%, three of 213), with a risk ratio of 5.72 (95% CI: 1.70-19.23). Interpretation: Azithromycin combined with low-dose methylprednisolone demonstrates non-inferior efficacy in reducing pulmonary lesions at 6-month follow-up compared to combined with high-dose methylprednisolone while exhibiting a more favorable safety profile.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Low‐dose versus high‐dose methylprednisolone for children with severe <i>Mycoplasma pneumoniae</i> pneumonia (MCMP): A randomized controlled trial
- Date Crossref
- 24/07/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Beijing Children’s Hospital Respiratory Department pays non établi dans la noticeÉtablissement de santé
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China Medical University Department of Pediatric pays non établi dans la noticeUniversité ou école supérieure
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Shanxi Provincial Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Capital Medical University Department of Respiratory Disease Beijing Children's Hospital pays non établi dans la noticeUniversité ou école supérieure
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Vanke (China) pays non établi dans la noticeEntreprise
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Tsinghua University pays non établi dans la noticeUniversité ou école supérieure
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Respiratory department Shanxi Children's Hospital Shanxi China Respiratory department pays non établi dans la noticeÉtablissement de santé
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Vanke School of Public Health pays non établi dans la noticeUniversité ou école supérieure
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The members of the MCMP Study Group are listed in the supporting information pays non établi dans la noticeInstitution
Respiratory Department — Beijing Children’s Hospital, Department of Pediatric — China Medical University et Shanxi Provincial Children's Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.