Cognitive Function, Physical Activity, and Sweat Cytokines in Older Adults With Dementia
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Le résumé fourni par la source
BACKGROUND: Inflammatory cytokines are linked to cognitive function in older adults with dementia; however, their associations with physical activity (PA) and noninvasive biomarkers, such as sweat, remain unclear. OBJECTIVES: This study aimed to examine the relationships among cognitive function, PA, and sweat cytokines, as well as the moderating effect of cognitive function on the association between PA and cytokine levels. METHODS: Data from 40 older adults with dementia were analyzed to assess correlations between cognitive function, PA measured via wearable devices, and sweat cytokine levels. Pearson's correlation, multiple linear regression, and the Johnson-Neyman method were employed to evaluate these associations. Interleukin-6 and tumor necrosis factor-alpha (TNF-α) levels were measured from sweat samples, and cognitive function was assessed using standardized cognitive tests. RESULTS: PA was positively associated with interleukin-6 and TNF-α, whereas lower cognitive function was linked to higher TNF-α levels. Cognitive function moderated the association between PA and TNF-α; specifically, higher PA was associated with lower TNF-α levels among participants with moderate-to-severe levels of dementia. DISCUSSION: These findings suggest that sweat cytokine measurement is a viable noninvasive biomarker for inflammatory responses in dementia and that the effect of PA on inflammation may be influenced by cognitive function. Nurses should consider patients' cognitive function when interpreting the association between PA and cytokine levels.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cognitive Function, Physical Activity, and Sweat Cytokines in Older Adults With Dementia
- Date Crossref
- 14/07/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ewha Womans University pays non établi dans la noticeUniversité ou école supérieure
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Yonsei University Mo-Im Kim Nursing Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Inha University pays non établi dans la noticeUniversité ou école supérieure
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Ethical Conduct of Research: The study was approved by the institutional review board (IRB No. 4-2024-0137) pays non établi dans la noticeStructure de recherche
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College of Nursing is Assistant Professor pays non établi dans la noticeUniversité ou école supérieure
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Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.nursingresearchonline.com) pays non établi dans la noticeInstitution
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School of Nursing is Assistant Professor pays non établi dans la noticeUniversité ou école supérieure
Ewha Womans University, Mo-Im Kim Nursing Research Institute — Yonsei University et Inha University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.