Longitudinal analysis of passively and actively acquired SARS-CoV-2 antibodies in infants with repeat newborn screening samples
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Le résumé fourni par la source
Large-scale studies that investigate longitudinal changes in SARS-CoV-2 antibody reactivity in newborn infants are limited. Infants acquire maternal IgG antibodies that decay after birth; if infected, they produce infant-derived IgG, IgA, and IgM antibodies. The New York State Newborn Screening Program (NYS NSP) collects dried blood spots (DBS) from infants at birth and follow-up specimens from a select group of infants, many of whom are premature. We tested 100,318 remnant DBS from 50,036 infants with repeat specimens received between November 2019 and November 2021 for SARS-CoV-2 IgG antibodies; 9611 infants were IgG reactive at birth and 630 seroconverted for SARS-CoV-2 IgG. The first infant seroconversion occurred in March 2020. Infants antibody-reactive at birth were less likely to have low or very low birthweight or be from a multiple birth; infants with repeat specimens were less likely to be reactive at birth than those with single specimens. Antibody decay occurred in a non-linear process with initial rapid decay followed by slower decay (half-life of 22-23 days for 0-30 days after birth, 37-38 days for > 30 days after birth). Seroconversion was confirmed by retesting IgG seroconverting infants for detectable IgA and IgM SARS-CoV-2 antibodies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Longitudinal analysis of passively and actively acquired SARS-CoV-2 antibodies in infants with repeat newborn screening samples
- Date Crossref
- 04/07/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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New York State Department of Health pays non établi dans la noticeOrganisme public
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Wadsworth Center pays non établi dans la noticeStructure de recherche
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University at Albany Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Albany College of Pharmacy and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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David Axelrod Institute Wadsworth Center pays non établi dans la noticeStructure de recherche
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College of Integrated Health Sciences Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
New York State Department of Health, Wadsworth Center et Department of Biological Sciences — University at Albany, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.