Monica M. Parker

Longitudinal analysis of passively and actively acquired SARS-CoV-2 antibodies in infants with repeat newborn screening samples

Amanda K. Damjanovic, Alexander C. Keyel, Jean M. Rock, Dylan J. Ehrbar et autres

Large-scale studies that investigate longitudinal changes in SARS-CoV-2 antibody reactivity in newborn infants are limited. Infants acquire maternal IgG antibodies that decay after birth; if infected, they produce infant-derived IgG, IgA, and IgM antibodies. The New York State Newborn Screening Program (NYS …

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Quantitating SARS-CoV-2 neutralizing antibodies from human dried blood spots

Katherine Gray Berman, Greta Van Slyke, Hayley Novak, Jean M. Rock et autres

In the earliest days of the COVID-19 pandemic, the collection of dried blood spots (DBS) enabled public health laboratories to undertake population-scale seroprevalence studies used to estimate rates of SARS-CoV-2 exposure. With SARS-CoV-2 seropositivity levels now estimated to exceed 94% in the …

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Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

Sally E. Wenzel, Michaela R. Anderson, Russell P. Tracy, Elizabeth A. Regan et autres

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Late Identification of Perinatal Transmission of HIV in an Infant at High Risk

Thomas J. O’Grady, Suzanne K. Kaufman, Amanda Stolz, Linda M. Styer et autres

The focus of this case study is the delayed diagnosis of a perinatal HIV transmission, which was identified when the infant reached 4 months of age, and the social conditions and structural determinants that contributed to the increased transmission risk. Despite adhering …

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Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots

Katherine Gray Berman, Greta Van Slyke, Hayley Novak, Jean M. Rock et autres

ABSTRACT Background In the earliest days of COVID-19 pandemic, the collection of dried blood spots (DBS) enabled public health laboratories to undertake population-scale seroprevalence studies to estimate rates of SARS-CoV-2 exposure. With SARS-CoV-2 seropositivity levels now estimated to exceed 94% in the …

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Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

John S. Kim, Yifei Sun, Pallavi Balte, Mary Cushman et autres

This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of …

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Abstract P540: Cardiovascular Disease Risk Factors and Antibody Response to COVID-19 Vaccination: The C4R Study

John S. Kim, Yifei Sun, Pallavi Balte, Mary Cushman et autres

Background: Adults with cardiovascular co-morbidities and risk factors are at greater risk of severe COVID-19. These same risk factors may also be associated with an attenuated antibody response to COVID-19 vaccines, although studies in diverse, U.S. population-based cohorts have been limited. Methods: …

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Use of Self-Collected Dried Blood Spots and a Multiplex Microsphere Immunoassay to Measure IgG Antibody Response to COVID-19 Vaccines

Katherine L. Nemeth, Erica Yauney, Jean M. Rock, Rachel Bievenue et autres

Serosurveys are an essential tool for assessing immunity in a population (1, 2). However, common barriers to effective serosurveys, particularly during a pandemic, include high-costs, resources required to collect venous blood samples, lack of trained laboratory technicians, and time required to perform …

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Utility of Newborn Dried Blood Spots to Ascertain Seroprevalence of SARS-CoV-2 Antibodies Among Individuals Giving Birth in New York State, November 2019 to November 2021

Amanda K. Damjanovic, Linda M. Styer, Katherine L. Nemeth, Erica Yauney et autres

Importance: Serosurveys can be used to monitor population-level dynamics of COVID-19 and vaccination. Dried blood spots (DBSs) collected from infants contain maternal IgG antibodies and are useful for serosurveys of individuals recently giving birth. Objectives: To examine SARS-CoV-2 antibody prevalence in pregnant …

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A cross‐sectional study of hepatitis C prevalence and correlates among persons who inject drugs in rural and non‐rural communities

Meredith A. Barranco, Eli Samuel Rosenberg, Colleen A. Flanigan, Sarah Shufelt et autres

Persons who inject drugs (PWID) have been experiencing a higher burden of new hepatitis C (HCV) due to the opioid epidemic. The greatest increases in injection have been in rural communities. However, less is known about the prevalence of HCV or its …

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Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

Elizabeth C. Oelsner, Akshaya Krishnaswamy, Pallavi Balte, Norrina B. Allen et autres

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have collected data on clinical and subclinical diseases …

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Postpartum Mother-To-Child Transmission of HIV in a Breastfeeding Infant

Carol-Ann E. Swain, Suzanne K. Kaufman, Wilson Miranda, Lisa Haskin et autres

This article is an examination of MTCT of HIV through breastfeeding in a mother who seroconverted postnatally.

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