[Exploring the Causal Relationship Between Circulating Immune Cells and Autoimmune Hepatitis Through Mendelian Randomization Analysis].

Le résumé fourni par la source

Objective: To elucidate the causal relationship between specific immune cells and autoimmune hepatitis (AIH) using a two-sample Mendelian randomization (MR) approach. Methods: A bidirectional MR analysis was conducted using data from large publicly accessible Genome-Wide Association Study (GWAS) databases. The inverse variance weighted (IVW) method was employed as the primary method to evaluate the relationship between 731 immune cell traits and AIH. The false discovery rate (FDR) was controlled using the Benjamini-Hochberg correction. Additionally, pleiotropy and heterogeneity tests were performed, and a leave-one-out sensitivity analysis was conducted to further validate the robustness of the results. Results: = 0.185) was associated with a reduced risk of AIH. Conclusion: Four immune cell phenotypes associated with AIH risk are identified. Further investigation is needed to validate these findings and explore new therapeutic avenues.

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