ChatGPT in the Management of Chronic Rhinosinusitis with Nasal Polyps: Promising Support or Digital Illusion? Insights from a Multicenter Observational Study
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Le résumé fourni par la source
Background/Objective: Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with a significant impact on quality of life and is frequently associated, from a pathogenetic perspective, with type 2 inflammation. The introduction of biologic therapies has marked a turning point in the management of severe forms of the disease, offering a valuable treatment option. However, selecting the most suitable biologic agent for a specific patient remains a clinical challenge. Artificial intelligence, and, in particular, ChatGPT, has recently been proposed as a potential tool to support medical decision-making and guide therapeutic choices. To evaluate the concordance between the therapeutic recommendations provided by ChatGPT and those of a multidisciplinary expert board in selecting the most appropriate biologic therapy for CRSwNP patients, based on the analysis of their phenotype and endotype. Methods: A multicenter observational cohort study was conducted. Clinical data from 286 patients with CRSwNP were analyzed. For each case, the therapeutic choice among Dupilumab, Mepolizumab, and Omalizumab was compared between the board and ChatGPT. Concordance rates and Cohen’s Kappa coefficient were calculated. Results: Overall concordance was 59.2%, with a Cohen’s Kappa coefficient of 0.116. Concordance by drug was 62.8% for Dupilumab, 26.5% for Mepolizumab, and 9.1% for Omalizumab. Patients presented with severe clinical profiles, with an average Nasal Polyp Score of 6.22 and an average SNOT-22 score of 64.5. Conclusions: This study demonstrates that, despite its substantial theoretical potential, ChatGPT is currently not a reliable tool for the autonomous selection of biological therapies in patients with CRSwNP. Further studies are necessary to enhance its reliability and integration into clinical practice.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- ChatGPT in the Management of Chronic Rhinosinusitis with Nasal Polyps: Promising Support or Digital Illusion? Insights from a Multicenter Observational Study
- Date Crossref
- 25/06/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Palermo Neuroscience and Advanced Diagnostic Department pays non établi dans la noticeUniversité ou école supérieure
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Università degli Studi di Enna Kore pays non établi dans la noticeUniversité ou école supérieure
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University of Catania Department of Medical-Surgical Sciences and Advanced Technologies pays non établi dans la noticeUniversité ou école supérieure
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University of Messina Department of Adult and Development Age Human Pathology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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Otorhinolaryngology Unit pays non établi dans la noticeOrganisation à but non lucratif
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Digital Consultant Freelance pays non établi dans la noticeInstitution
Neuroscience and Advanced Diagnostic Department — University of Palermo, Università degli Studi di Enna Kore et Department of Medical-Surgical Sciences and Advanced Technologies — University of Catania, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.