454-P: Impact of Exercise Training on Cardiac Function in Individuals with Obesity with and without Type 2 Diabetes Using Cardiac and 4D Flow MRI

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Introduction and Objective: Type 2 diabetes (T2D) and obesity are associated with left ventricular (LV) dysfunction, but the impact of exercise interventions on LV function remains unclear. This study aims to assess LV function in individuals with obesity, with and without T2D via supervised aerobic exercise training, using cardiac MRI and time-resolved three-dimensional phase-contrast MRI (4D flow MRI). Methods: 16 overweight controls (OWC; HbA1c = 5.3 ± 0.2%; age = 42.8 ± 6.0 years; 56% female) and 7 individuals with obesity and T2D (HbA1c = 6.8 ± 0.8%; age = 48.3 ± 6.0 years; 57%) completed 15 weeks of exercise training. Maximal oxygen consumption was measured as a marker of cardiorespiratory fitness. Global LV function and strain were analyzed using cardiac MRI. E/A velocity, a standard echocardiographic marker, was assessed using 4D flow MRI. Participants were categorized into low SVi (20.5 ± 3.0 mL/m2) and high SVi groups (30.1 ± 3.6 mL/m2) based on an SVi threshold of 25 mL/m2. Pre- and post-exercise data were compared using paired t-tests. Results: Reclassifying the cohort by SVi showed a significant increase in E/A velocity only in the high SVi group after exercise, with no other biomarkers showing significant changes in either group. Conclusion: Early LV function changes via exercise intervention may be detectable in E/A velocity in individuals with high SVi. Disclosure S. Park: None. E.K. Englund: None. T. Fujiwara: None. D. Enge: Employee; Epic. M. Schäfer: None. B.M. Fonseca: Consultant; Siemens Healthcare Diagnostics. K.S. Hunter: None. J.G. Regensteiner: None. J.E.B. Reusch: Advisory Panel; Medtronic. A.J. Barker: None. Funding American Diabetes Association (4-24-PDF-51)

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