Jane E.B. Reusch

Sex Differences Across the Lifespan: A Focus on Cardiometabolism and Mental Health

T. Rajendra Kumar, Jane E.B. Reusch, Wendy M. Kohrt, Judith G. Regensteiner et autres

The Ludeman Family Center for Women' s Health Research (Ludeman Center) at the University of Colorado (cwhr@ucdenver.edu) organized its 4th National Conference at The Broadmoor Hotel in Colorado Springs, CO. The research presentations and discussions from the three-day October 2024 conference addressed …

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International Society of Nephrology International Expert Forum: Exploring the Nexus of Cardiovascular-Kidney-Metabolic Health

Roberto Pecoits-Filho, Debasish Banerjee, Meg J. Jardine, Brendon Neuen et autres

The cardiovascular-kidney-metabolic framework recognizes the interconnected biological, clinical, and societal drivers of cardiovascular disease, chronic kidney disease, diabetes, and obesity. To advance an integrated perspective, aligned with the kidney community focus, the International Society of Nephrology convened an International Expert Forum, bringing …

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Still in the dark: effects of sex differences on statin-associated diabetes risk

Pandora L. Wander, ANA J. PINTO, Mary O. Whipple, Alyssa S. Carlson et autres

Statins reduce cardiovascular risk but modestly increase type 2 diabetes (T2D). Evidence is limited by underrepresentation of women and lack of sex-specific analyses. In an umbrella review and meta-analysis of 21 trials with sex-disaggregated data, statins increased T2D risk similarly in women …

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol

Kristine M. Erlandson, Laurel Gustafson, Julia E Johnson, Grace L. Ditzenberger et autres

BACKGROUND: The Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH) study is a randomised controlled trial with the overall goal of examining the combined effect of exercise and the growth hormone-releasing hormone analogue tesamorelin on physical function. …

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Characterization and validation of EHR computable phenotypes for Long COVID using patient-reported symptoms: insights from the nationwide RECOVER program

Victor M Castro, Vivian Gainer, Nich Wattanasin, Andrew Cagan et autres

OBJECTIVE: Long COVID (LC) remains poorly understood, and there is a critical need for advanced computational tools to better identify and characterize patients. In this study, we use summarized symptom reports by RECOVER-Adult cohort participants linked to EHR data to characterize patients …

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Convergent human genetic evidence implicates serine biosynthesis in diabetic peripheral neuropathy

Vera Fridman, Aastha Kakar, A. E. Jensen, Liedewei Van de Vondel et autres

Abstract Background Diabetic peripheral neuropathy (DPN) is a common and disabling complication of diabetes for which no disease-modifying therapies are currently available. Glycemic and metabolic drivers do not fully explain why only a subset of individuals with diabetes develop DPN, and underling …

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2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Chiadi E. Ndumele, Fatima Rodriguez, Dave L. Dixon, Sadiya S. Khan et autres

AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults." The primary intended audience for this guideline is clinicians …

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Disrupting clinical inertia: Personalizing cardiovascular risk to transform cardiometabolic care in the real world

Layla A. Abushamat, Jane E.B. Reusch, Christie M. Ballantyne

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Among individuals who die of COVID-19, is the percentage who had diabetes actually higher than in those dying of other viral infections?

Neha V Reddy, Virginia Pate, Til Stürmer, Rachel Wong et autres

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The Effect of COVID‐19 on Incident Diabetes in Pediatric Patients: Findings From the National COVID‐19 Cohort Collaborative (N3C)

Jane E.B. Reusch, Zachary Butzin-Dozier, Jared D. Huling, Rachel Wong et autres

Studies showing increased diabetes incidence in pediatric patients after COVID‐19 are from data early in the pandemic, and some studies found conflicting results. Our objective was to evaluate trends in pediatric diabetes incidence and whether COVID‐19 was associated with increased risk across …

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Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus

Sung Ho Park, Erin K. Englund, Takashi Fujiwara, Daniel Enge et autres

AIMS: This study aimed to assess the impacts of overweight and type 2 diabetes (T2D) on early hemodynamic and left ventricular (LV) changes using comprehensive cardiovascular magnetic resonance imaging (CMR) in three age- and sex-similar groups: lean individuals (LI group), BMI-similar overweight …

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MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes

Tyler Dobbs, Peng Hu, Kendall S. Hunter, Brian Fonseca et autres

BACKGROUND: Adolescents with youth-onset type 2 diabetes (YO-T2D) have an increased risk for cardiometabolic complications. The impact of vertical sleeve gastrectomy (VSG) on fat distribution and cardiac morphology/function in YO-T2D is unknown. OBJECTIVES: To evaluate changes in body composition, abdominal and cardiac …

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