Abstract 2356 Bmal1-Clock desynchrony impacts monocyte trafficking via activation of CXCR4/CCR2 chemotaxis pathway

Le résumé fourni par la source

Chemokine receptors (Cxcr4 and Ccr2) are implicated as modulators of monocyte trafficking and migration in mammals. Circadian oscillations of these chemokines have a regulatory role in patterning monocyte migration and inflammatory responses. Disruptions in circadian oscillations of monocytes is known to aggravate the pro-inflammatory response in autoimmune, metabolic and systemic chronic inflammatory disorder but the mechanistic details of key regulators and affected pathways lacks clarity. Herein, we hypothesize that Bmal1-Clock heterodimer binds to the E-box elements present in the 5' UTR promotor region of the chemokine receptors, regulating the monocyte migration via alterations in chemotaxis pathway leading to increased recruitment of inflammatory monocytes.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.