Functional, Pulmonary, Psychological and Cognitive Status Up to 12 Months Post-ICU Discharge in COVID-19 Patients: A Preliminary Analysis of the International Aftercor Study
Rattachement africain : ch, it, au, es, co, sg, ie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Long-term sequelae associated with COVID-19 are currently poorly defined, specifically in patients who have been discharged from intensive care units. We hypothesized that functional and pulmonary capacity, as well as mental health and cognitive function, would remain outside the normal range for up to 12 months after ICU discharge. Methods This is an international multicenter, prospective follow-up study of patients admitted to ICU due to COVID-19 (1). At 3, 6 and 12 months after ICU discharge, the following assessments were done: 6-minute walking test, Barthel Index Score (BIS), WHODAS score, spirometry, lung diffusion capacity for carbon monoxide (DLCO), Hospital Anxiety and Depression Scale (HADS), Patient Health Questionnaire-9 (PHQ-9) and the Montreal Cognitive Assessment (MoCA). Normalized test results at any follow-up assessment were not repeated at subsequent visits. Results 354 patients from 9 sites in 6 countries (Ireland, Spain, Italy, USA, Singapore, Colombia) admitted to ICU from January 2021 to December 2022 for COVID-19 were included. Median (IQR) age was 60 years (SD 13.3y), 32.5% were females, and 22 patients (6.2%) died during follow-up. The 6-min walking test was outside a normal range in 97.7%, 98% and 99.1% of the patients at 3, 6 and 12 months, with a mean walking distance of 359, 392 and 433 meters, respectively (Fig.1A). The BIS score was not normalized in 12.4%, 23.5% and 28% (Fig.1B), the WHODAS score in 22.2%, 56.4% and 45.2% (Fig.1C) at 3, 6 and 12 months, respectively. FVC and FEV1 were outside normal limits in 64.3% of the patients at 3 months, 34.7% and 32.9% at 6 months, 33.8% and 27.7% at 12 months (Fig.1D/E). DLCO was abnormal in 62.4%, 78.4% and 80.6% (Fig.1F) of patients, at 3, 6 and 12 months. As shown by the HADS, anxiety was present in 28.9%, 26.9% and 32.7% (Fig.1G) of the patients, while 30.2%, 26.9% and 32.7% (Fig.1H) had significant depression at 3, 6 and 12 months. The PHQ-9 was outside normal range in 66.4%, 66.2% and 72.2% (Fig 1I) of the patients, while the MOCA test revealed cognitive impairment in 40.8%, 30% and 32.5% of the patients at 3, 6 and 12 months. Conclusion The assessment of COVID-19 patients up to 12 months post-ICU discharge indicates that pulmonary function and mental health remain outside the normal range in a significant proportion of patients, with one-third of patients experiencing cognitive impairment. A comprehensive evaluation of the pre-ICU admission status is currently underway.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Functional, Pulmonary, Psychological and Cognitive Status Up to 12 Months Post-ICU Discharge in COVID-19 Patients: A Preliminary Analysis of the International Aftercor Study
- Date Crossref
- 01/05/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University Hospital of Basel pays non établi dans la noticeÉtablissement de santé
-
IRCCS Policlinico San Donato ICU pays non établi dans la noticeÉtablissement de santé
-
Policlinico Universitario di Catania pays non établi dans la noticeÉtablissement de santé
-
University of Genoa pays non établi dans la noticeUniversité ou école supérieure
-
World Health Organization pays non établi dans la noticeOrganisme public
-
The Alfred Hospital ICU pays non établi dans la noticeÉtablissement de santé
-
Hospital Universitari de Tortosa Verge de la Cinta pays non établi dans la noticeÉtablissement de santé
-
Griffith University pays non établi dans la noticeUniversité ou école supérieure
-
Universidad de La Sabana pays non établi dans la noticeUniversité ou école supérieure
-
Tan Tock Seng Hospital ICU pays non établi dans la noticeÉtablissement de santé
-
University Hospital Galway Anesthesia pays non établi dans la noticeÉtablissement de santé
-
Tallaght University Hospital ICU pays non établi dans la noticeÉtablissement de santé
University Hospital of Basel, ICU — IRCCS Policlinico San Donato et Policlinico Universitario di Catania, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.