Plasma Vitamin B12 May Be a Misleading Biomarker among Children with Severe Acute Malnutrition: An Observation from Mwanza, Tanzania
Rattachement africain : dk, Tanzanie, gb, fi. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Vitamin B12 deficiency is related to impaired neurodevelopment and anemia and is a global health concern in children with severe acute malnutrition (SAM). OBJECTIVES: We investigated vitamin B12 status in children with SAM and among non-malnourished comparisons and assessed the validity of the plasma vitamin B12 assay. METHODS: This study was part of a pilot study of a nutritional intervention. We measured plasma concentrations of vitamin B12, methylmalonic acid (MMA), total haptocorrin (HC), and total transcobalamin (TC) in children with SAM before and after 8 wk of nutritional treatment and at a single timepoint in non-malnourished children. RESULTS: We included 82 children with SAM and 82 children without acute malnutrition. Plasma vitamin B12 was higher in children with SAM at enrollment than in controls (median 647 compared with 411 pmol/L) and declined after treatment (median 469 pmol/L). Baseline plasma vitamin B12 was particularly high in children with edematous SAM compared to those without edema (P = 0.050). In contrast, plasma MMA was higher in those with SAM, reflecting lower vitamin B12 function (median 220 compared with 170 nmol/L), and declined after treatment (median 190 nmol). HC was positively correlated with vitamin B12 concentration (P < 0.001) and was also higher in children with SAM than in comparison children (median 959 compared with 789 pmol/L), decreasing after treatment (median 815 pmol/L). TC was higher in children with SAM than comparisons but did not decrease after treatment. Overall, 23% of children with SAM had MMA concentrations suggesting vitamin B12 deficiency compared to 4.5% of non-malnourished children. CONCLUSIONS: In contrast to our initial expectations, we found that plasma vitamin B12 was higher in children with SAM, especially those with edema. However, analysis of MMA revealed lower vitamin B12 function in malnourished children and improvement after treatment, warranting caution in the interpretation of plasma vitamin B12 in SAM. Elevated HC in SAM may explain high vitamin B12 concentration, but the cause of elevated HC needs further investigation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Plasma Vitamin B12 May Be a Misleading Biomarker among Children with Severe Acute Malnutrition: An Observation from Mwanza, Tanzania
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Rigshospitalet Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Aarhus University Hospital Department of Clinical Biochemistry pays non établi dans la noticeÉtablissement de santé
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National Institute for Medical Research Dar es Salaam, Tanzanie (code pays fourni par la source)Structure de recherche
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Catholic University of Health and Allied Sciences Mwanza, Tanzanie (code pays fourni par la source)Université ou école supérieure
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London School of Hygiene & Tropical Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Liverpool Department of Women and Children's Health pays non établi dans la noticeUniversité ou école supérieure
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Liverpool Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Tampere University pays non établi dans la noticeUniversité ou école supérieure
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University of Copenhagen Department of Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Copenhagen University Hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Epidemiology and Population Health pays non établi dans la noticeUniversité ou école supérieure
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London School of Hygiene and Tropical Medicine (LSHTM) pays non établi dans la noticeUniversité ou école supérieure
Department of Infectious Diseases — Rigshospitalet, Department of Clinical Biochemistry — Aarhus University Hospital et National Institute for Medical Research (Dar es Salaam, Tanzanie), avec 9 autres affiliations. Pays d’affiliation : Tanzanie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.