Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets

Le résumé fourni par la source

OBJECTIVE: Oxytocin (Oxt) is secreted to the peripheral body through the pituitary gland and can induce insulin secretion under high glucose conditions. Insulin secretion is regulated by various factors including glucagon-like peptide (GLP)-1, secreted from intestinal L-cells. GLP-1 is also expressed and secreted within islets and termed as "intra-islet GLP-1". The study aims to elucidate the impact of Oxt on insulin secretion in relation to intra-islet GLP-1. METHODS: channel activity were also investigated. RESULTS: Oxt injection induced a temporal rise in blood glucose levels in both WT and OxtR-KO mice at 15-min post-injection. In WT mice, blood glucose level returned to control levels by 30min and were significantly lower at 60-min. OxtR KO mice maintained elevated glucose levels at 30-min. WT mice showed a significant increase in insulin levels at 15-min, while OxtR KO mice did not. OxtR was expressed in both insulin and glucagon-positive cells with higher expression in glucagon-positive cells. WT islets showed an increase in intra-islet GLP-1 secretion upon Oxt application. CONCLUSIONS: The study indicates that Oxt may enhance insulin secretion by promoting the secretion of intra-islet GLP-1.

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