Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The incidence of clear cell renal cell carcinoma (ccRCC) has steadily increased over the past decade, and recent studies have linked bile acid (BA) metabolism to its development. However, the metabolic profile of BAs and their potential as biomarkers in ccRCC pathogenesis remain poorly characterized, making their evaluation crucial for advancing disease understanding and management. METHODS: A total of 68 newly diagnosed ccRCC patients and 63 healthy controls were enrolled. Serum bile acid (BA) profiles were measured using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS). The Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) model analyzed differences in serum BA profiles between ccRCC patients and controls. Additionally, the relationship between BA profiles and tumor heterogeneity parameters was investigated. Receiver Operating Characteristic (ROC) analysis identified potential biomarkers for ccRCC pathogenesis. RESULTS: The BA profile was altered in ccRCC patients and was not influenced by sex or age. Specifically, primary and secondary unconjugated BA fractions were significantly higher in the ccRCC population. Five BA metabolite candidates exhibited the most significant differences between ccRCC patients and controls. Deoxycholic acid (DCA) was associated with pathological pTNM stage classification and grade. Chenodeoxycholic acid (CDCA) and lithocholic acid (LCA), combined with testosterone, showed potential as biomarkers for the pathogenesis of ccRCC. CONCLUSION: Alterations in the serum BA profile are observed in ccRCC. Deoxycholic acid (DCA) correlates with pathological pTNM stage classification and tumor grade. Additionally, CDCA combined with LCA show potential as biomarkers for ccRCC pathogenesis. CLINICAL TRIAL NUMBER: Not applicable.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression
- Date Crossref
- 23/04/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Jiangsu University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
-
Soochow University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
-
Xuzhou Cancer Hospital pays non établi dans la noticeÉtablissement de santé
-
Affiliated Hospital of Jiangsu University pays non établi dans la noticeÉtablissement de santé
-
First Affiliated Hospital of Soochow University pays non établi dans la noticeÉtablissement de santé
-
Yancheng Third People's Hospital pays non établi dans la noticeÉtablissement de santé
-
Yancheng Second People's Hospital pays non établi dans la noticeÉtablissement de santé
-
Nanjing University of Chinese Medicine Department of Urology pays non établi dans la noticeUniversité ou école supérieure
-
Suzhou Traditional Chinese Medicine Hospital pays non établi dans la noticeÉtablissement de santé
-
Dongtai People Hospital Department of Urology pays non établi dans la noticeÉtablissement de santé
Department of Urology — Jiangsu University, Department of Urology — Soochow University et Xuzhou Cancer Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.