Guihua Zhang

Identification of stable QTL for yield-related traits in a durum wheat Svevo × Zavitan RIL population

Xinli Zhou, Bingchuan Zhou, Guihua Zhang, Gaoying Zou et autres

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A Case Report and Literature Review of Hereditary Myopathy with Early Respiratory Failure

Huaying Shi, Guihua Zhang, Dan Ren, Wenxu Zheng et autres

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MeJA-responsive MYB41-MYC2 cascade integrates glucomannan biosynthesis and DoTIP1–1 activation during salinity tolerance in Dendrobium officinale

F. C. Zheng, Xiaoji Deng, Guihua Zhang, Jaime A Teixeira da Silva et autres

Abstract Soil salinization limits the yield and quality of Dendrobium officinale. The molecular mechanisms linking methyl jasmonate (MeJA) signaling to the biosynthesis of glucomannans (GMs) under salinity remain unclear. In the WGCNA of MeJA- and salinity-treated D. officinale transcriptome, an R2R3-MYB transcription …

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Nanotechnology‐Enabled Targeted Protein Degradation: Strategies, Opportunities, and Challenges

Haoran Zhu, Yijun Zhang, Yuhua Ning, Chaoyong James Yang et autres

Targeted protein degradation (TPD) has redefined the therapeutic landscape by shifting the focus from merely inhibiting protein function to actively eliminating disease-causing proteins. However, the clinical translation of TPD agents remains hampered by their inherent physicochemical limitations, including poor solubility, membrane impermeability, …

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Algorithmic performance appraisal intensity in hospitals: implications for professional autonomy and innovative work behavior

Qing Yang, Shuang Li, Kai Wang, Xin Chang et autres

Introduction Hospitals increasingly use algorithmic systems to monitor, compare, score, and appraise employees. Although such systems may improve consistency and efficiency, intensive use may constrain medical professionals’ autonomy and their innovative behavior. This study examined the relationships among algorithmic performance appraisal intensity, …

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Revalidation of Manis aurita based on integrative genomic and morphological evidence

Narayan Prasad Koju, Zeling Zeng, Guihua Zhang, Zhicheng Yao et autres

Pangolins face severe conservation threats globally, necessitating accurate taxonomy for effective conservation. Previous genomic research on the Chinese pangolin (Manis pentadactyla) identified two deeply divergent lineages (MPA and MPB), suggesting underestimated species diversity. The recent description of M. indoburmanica (corresponding to MPB), …

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Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer

Mackenzie Brandon‐Coatham, Julia Avian Vassalakis, Jasleen Kaur, Farzaneh Afzali et autres

ABSTRACT Dedifferentiated endometrial carcinoma (DDEC) is a histologically unique cancer type, wherein well-differentiated regions lie adjacent to morphologically distinct, high-grade lesions that are histologically undifferentiated. Previous studies have determined that in nearly half of the cases dedifferentiation is associated with the genomic …

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Publisher Correction: Single-cell and bulk transcriptomics uncovers PRKD2-driven tumor stemness and progression in multiple myeloma

Guihua Zhang, Shengya Cao, Chong Geng, Yueyue Sun et autres

The original version of this Article contained an error in the order of the Figures. Figure 1 was published as Figure 3, Figure 2 was published as Figure 1, Figure 3 was published as Figure 4, Figure 4 was published as Figure …

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Effect of colonoscopy screening on the risk of colorectal cancer in China: a follow-up study

Yunxin Kong, Liu De, Yue Ma, Zongmei Dong et autres

Background Colorectal cancer (CRC) is one of the most common cancers worldwide. Colonoscopy is the gold standard for CRC screening, but its effectiveness in population-based programs requires further evaluation. Methods We conducted a follow-up study in Xuzhou, China. Participants were recruited from …

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Single-cell and bulk transcriptomics uncovers PRKD2-driven tumor stemness and progression in multiple myeloma

Guihua Zhang, Shengya Cao, Chong Geng, Yueyue Sun et autres

Multiple myeloma (MM) remains incurable, as most patients relapse or become refractory (RRMM), and the molecular nexus among clonal evolution, immune escape and therapy response remains unknown. Bulk RNA-seq from 24 MM to 6 matched marrows (subset of 132) plus single-cell datasets …

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Physics-informed machine learning for combustion: A review

Jiahao Wu, Xutun Wang, Guihua Zhang, Jiayue Liu et autres

Physics-informed machine learning (PIML) represents an emerging paradigm that integrates various forms of physical knowledge into machine learning (ML) components, thereby enhancing the physical consistency of ML models compared to purely data-driven paradigms. The field of combustion, characterized by a rich foundation …

The impact of prehabilitation strategies on psychological state, glucose metabolism, and postoperative outcomes in patients undergoing laparoscopic sleeve gastrectomy

Yan Zhang, Bingquan Gao, Xiaocheng Zhang, Xu Han et autres

OBJECTIVE: This study aims to explore the effects of prehabilitation strategies on the psychological state and glucose metabolism markers in patients undergoing laparoscopic sleeve gastrectomy (LSG). METHODS: A total of 120 eligible patients undergoing elective LSG between January 2024 and December 2024 …

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