Accès ouvert déclaré 2025 article

Electronic Nicotine Delivery Systems Use and Nicotine Exposure Among Adults Who Use ENDS Alone or With Cigarettes: The Population Assessment of Tobacco and Health Study 2013–2019

Kathryn C. Edwards, Katherine V. Garcia-Rosales, Maciej Lukasz Goniewicz, David L. Ashley, Dorothy K. Hatsukami, Lanqing Wang, Jun Feng, Benjamin C. Blount, Eva Sharma, Lori S. Merrill, Kristie A. Taylor, Kara Duffy, Arit M. Harvanko, Arseima Y. Del Valle-Pinero, Carol H. Christensen, Cindy M. Chang, Dana M. van Bemmel, Derick L. Rivers, Elena V. Mishina, Eric A. Tolliver, Esther J. Roh, Hoda T. Hammad, Prabha Kc, Kerui Xu, Ruben Montes de Oca, Yu‐Ching Cheng, Colm D. Everard, Heather L. Kimmel, Carlos Blanco, Wilson M. Compton, Andrew J. Hyland

2Citations signalées, ce qui n’est pas une note de qualité

8Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : us. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

INTRODUCTION: Evaluating nicotine exposure (total nicotine equivalents-2; TNE-2) changes over time can provide data on the public health impact of electronic nicotine delivery systems (ENDS). This study describes TNE-2 levels of those who use ENDS with or without cigarettes from 2013-2019, and models how changing ENDS use behavior impacts change in TNE-2. AIMS AND METHODS: Creatinine-corrected TNE-2 was assessed for exclusive ENDS use and dual ENDS and cigarette use from Waves (W) 1-5 of the Population Assessment of Tobacco and Health Study. Exploratory analyses using generalized estimated equations modeled how changing ENDS use (ie, frequency of use, flavor use, device type) between wave pairs (W1-W2, W2-W3, etc.) impacted changes in TNE-2. RESULTS: For exclusive ENDS use at each wave, TNE-2 levels increased from 10.1 µmol/g at W1 to 18.4 µmol/g at W5, a positive linear trend (p = .03). Among those who exclusively used ENDS at all waves, TNE-2 levels peaked at W3 and then decreased at W5, exhibiting a significant quadratic trend (p = .02). Switching from non-daily to daily use (n = 15) was associated with a greater increase in TNE-2 than continued daily use (n = 304). For dual use, TNE-2 levels remained relatively flat, and there were no significant effects of changing ENDS behavior on TNE-2. CONCLUSIONS: For exclusive ENDS use, TNE-2 levels over time differ when looking within-subjects versus repeated longitudinal assessments, and frequency of use was the only significant predictor of change in TNE-2. TNE-2 from dual-use did not significantly change from 2013-2019 and was not impacted by change in ENDS use behavior. IMPLICATIONS: Exclusive ENDS use was associated with a positive linear trend in nicotine exposure between 2013 and 2019, which may reflect how newer generations of ENDS are better at delivering nicotine. When limiting analysis to within-subject use at all waves the trend was quadratic, with nicotine exposure peaking at W3 and returning toward W1 levels by W5. This may be related to people trying to titrate their nicotine exposure in response to changes in ENDS characteristics. Dual ENDS and cigarette use had more consistent levels of exposure over time, which could be due to the greater ease of nicotine titration via cigarettes.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Electronic Nicotine Delivery Systems Use and Nicotine Exposure Among Adults Who Use ENDS Alone or With Cigarettes: The Population Assessment of Tobacco and Health Study 2013–2019
Date Crossref: 20/04/2025
Éditeur: Oxford University Press (OUP)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Roswell Park Comprehensive Cancer Center pays non établi dans la notice
Structure de recherche
Westat (United States) pays non établi dans la notice
Entreprise
University of Minnesota pays non établi dans la notice
Université ou école supérieure
Centers for Disease Control and Prevention pays non établi dans la notice
Organisme public
National Center for Environmental Health pays non établi dans la notice
Structure de recherche
Center for Tobacco Products pays non établi dans la notice
Organisme public
National Institute on Drug Abuse pays non établi dans la notice
Structure de recherche
Kelly Services (United States) pays non établi dans la notice
Entreprise
TRS Consulting56 pays non établi dans la notice
Institution
Division of Laboratory Sciences pays non établi dans la notice
Structure de recherche
Kelly Government Solutions pays non établi dans la notice
Institution

Roswell Park Comprehensive Cancer Center, Westat (United States) et University of Minnesota, avec 8 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

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