Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis
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Le résumé fourni par la source
Introduction: Although age is the most important non-modifiable risk factor for cerebral stroke, it is also apparent that females commonly exhibit longer lifespan and better outcome after stroke compared to the age-matched males. A critical event after stroke is the peripheral infiltration of immune cells across damaged blood-brain barrier, which induces inflammatory and immune responses within the brain parenchyma and consequently worsen brain injury. These events are also dependent on age and display a sex different pattern. Theoretically, X chromosome-encoded differential expression genes (DEGs) may explain differences between the sexes. However, the expression and regulation of these DEGs after stroke have not been studied in detail. Methods: We conducted three datasets of human blood cells, mice brain, mice microglia and T cells that were previously published, and analyzed the contribution of gender, age and stroke insult on the X chromosome-encoded DEGs. Results: The main findings were (i) compared to age, the stroke/hypoxia was a more potent factor in eliciting the DEGs. Particularly, older stroke patients exhibited more changes compared to young stroke group. (ii) After a stroke, the DEGs was diversely influenced by sex, age and cell types being studied. Particularly, either aging or gender led to more striking changes in brain-infiltrating T cells than in the resident immune cells. Discussion: These findings highlight the complex interplay between sex, age, and immune responses in mediating stroke incidence and outcome. Investigation of the identified X chromosome-encoded genes in brain-infiltrating T cells deserves high priority, as they may play more important roles in explaining gender-related differences in stroke and brain injury.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis
- Date Crossref
- 21/03/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangzhou University of Chinese Medicine Department of Neurology and Psychology pays non établi dans la noticeUniversité ou école supérieure
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Shenzhen Traditional Chinese Medicine Hospital pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Sciences pays non établi dans la noticeOrganisme public
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Fujian Institute of Research on the Structure of Matter pays non établi dans la noticeStructure de recherche
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Shenzhen University Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Minzu University of China pays non établi dans la noticeUniversité ou école supérieure
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Houston Methodist Systems Medicine and Bioengineering pays non établi dans la noticeÉtablissement de santé
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Methodist Hospital pays non établi dans la noticeÉtablissement de santé
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State Key Lab of Structural Chemistry pays non établi dans la noticeStructure de recherche
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School of Public Health pays non établi dans la noticeUniversité ou école supérieure
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College of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
Department of Neurology and Psychology — Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital et Chinese Academy of Sciences, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.