Epidemiology of Coronary Atherosclerosis Among People Living With HIV in Uganda
Rattachement africain : us, Ouganda, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Data on the prevalence of coronary atherosclerotic disease (CAD) in the African region among people with and without HIV are lacking. OBJECTIVE: To estimate the prevalence of CAD in Uganda and determine whether well-controlled HIV infection is associated with increased presence or severity of CAD. DESIGN: Cross-sectional study. SETTING: Southwestern Uganda. PARTICIPANTS: Ambulatory people living with HIV (PWH), aged older than 40 years, taking antiretroviral therapy for 3 or more years, and population-based, age- and sex-similar people without HIV (PWoH). MEASUREMENTS: Participants had cardiovascular (CV) disease (CVD) risk profiling and computed tomography scanning for detection of CAD, defined as the presence of calcified or noncalcified plaque. RESULTS: Of 630 screened, 586 (93%) met criteria and had evaluable images. Of these, 287 (49.0%) were PWH and nearly all (272 of 287 [95%]) were virologically suppressed. Mean age (57.9 vs. 57.4 years), proportion female (49%), and median CVD risk score (4.1 vs. 3.4) did not differ by HIV serostatus. The prevalence of CAD was low overall (45 of 586 [7.7%]) and among both PWH (26 of 287 [9.1%]) and PWoH (19 of 299 [6.4%]; absolute prevalence difference, 2.7% [95% CI, -1.6% to 7.0%]). Results were similar after adjustment for CVD risk factors. LIMITATIONS: Our findings may not generalize to symptomatic populations or those with greater predicted CVD risk. The study was not powered to detect small differences in CAD prevalence between HIV subgroups. Both PWH and PWoH had similar CV risk factor profiles, but residual confounding between HIV and CAD cannot be excluded. CONCLUSION: The prevalence of CAD in Uganda was low compared with population-based cohorts from the Global North with similar CVD risk profiles and was similar between HIV serostatus subgroups. Our results suggest that CAD may not be a major cause of morbidity in Uganda. PRIMARY FUNDING SOURCE: National Institutes of Health.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Epidemiology of Coronary Atherosclerosis Among People Living With HIV in Uganda
- Date Crossref
- 01/04/2025
- Éditeur
- American College of Physicians
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Mbarara University of Science and Technology Massachusetts General Hospital Mbarara, Ouganda (code pays fourni par la source)Université ou école supérieure
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Massachusetts General Hospital pays non établi dans la noticeÉtablissement de santé
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Africa Health Research Institute KwaZulu-Natal, Afrique du Sud (code pays fourni par la source)Structure de recherche
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University of KwaZulu-Natal University of KwaZulu-Natal, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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Nsambya Hospital Kampala, Ouganda (code pays fourni par la source)Établissement de santé
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Makerere University Makerere University, Ouganda (code pays fourni par la source)Université ou école supérieure
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Mulago Hospital Ouganda (code pays fourni par la source)Établissement de santé
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Yale University pays non établi dans la noticeUniversité ou école supérieure
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Joint Clinical Research Centre Ouganda (code pays fourni par la source)Organisation à but non lucratif
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South African Medical Research Council Afrique du Sud (code pays fourni par la source)Institution
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University of Cape Town Department of Medicine University of Cape Town, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
Harvard University, Massachusetts General Hospital — Mbarara University of Science and Technology (Mbarara, Ouganda) et Massachusetts General Hospital, avec 9 autres affiliations. Pays d’affiliation : Ouganda, Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.