Accès ouvert déclaré
2025
article
Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study
Dorine Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud Nijman, Ulrich von Both, Marieke Emonts, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian Maconochie, Federico Martinón‐Torres, Marko Pokorn, Irene Rivero‐Calle, Aleksandra Rudzāte, Chantal Tan, Μαρία Τσολιά, Clementien Vermont, Dace Zavadska, Werner Zenz, Henriëtte A. Moll, Nienke N. Hagedoorn, Willem A. Dik, Stéphane Paulus, Elizabeth Cocklin, Rebecca B. Jennings, Joanne Johnston, Simon Leigh, Karen Newall, Sam Romaine, Aubrey J. Cunnington, Tisham De, Myrsini Kaforou, Victoria Wright, Lucas Baumard, Evangelos Bellos, Giselle D’Souza, Rachel Galassini, Dominic Habgood-Coote, Shea Hamilton, Clive Hoggart, Sara Hourmat, Heather Jackson, Stephanie Menikou, Naomi Lin, Samuel Nichols, Ivonne Pena Paz, Priyen Shah, Ching‐Fen Shen, Ortensia Vito, Clare Wilson, Amina Abdulla, Ladan Ali, Sarah Darnell, Rikke Jørgensen, Sobia Mustafa, Salina Persand, Laura Kolberg, Manuela Zwerenz, Judith Buschbeck, Christoph Bidlingmaier, Vera Binder, Katharina Danhauser, Nikolaus Haas, Matthias Griese, Tobias Feuchtinger, Julia Keil, Matthias Kappler, Eberhard Lurz, Georg Muench, Karl Reiter, Carola Schoen, Lucille Valentine, Karen N. Allen, Kathryn Bell, Adora Chan, Stephen Crulley, Kirsty Devine, Daniel Fabián, Sharon King, Paul McAlinden, Sam McDonald, Anne McDonnell, Ailsa Pickering, E. Thomson, Amanda Wood, Diane Wallia, Phil Woodsford, Frances Baxter, Ashley Bell, Mathew Rhodes, Rachel Agbeko, Christine Mackerness, Bryan Baas, Lieke Kloosterhuis, Wilma Oosthoek, Tasnim Arif, Joshua Bennet, Kalvin Collings, Ilona van der Giessen, Alex Martin, Aqeela Rashid, Emily Rowlands, Gabriella de Vries, Fabian van der Velden, Mike Martin, Ravi Mistry, Mistry Zenz, Nina A. Schweintzger, Manfred G. Sagmeister, Daniela S. Kohlfürst, Christoph Zurl, Alexander Binder, Susanne Hösele, Manuel Leitner, Lena Pölz, Glorija Rajic, Sebastian Bauchinger, Hinrich Baumgart, Martin Benesch, Astrid Ceolotto, Ernst Eber, Siegfried Gallistl, Gunther Gores, Harald Haidl, Almuthe Hauer, Christa Hude, Markus Keldorfer, Larissa Krenn, Heidemarie Pilch, Andreas Pfleger, Klaus Pfurtscheller, Gudrun Nordberg, Tobias Niedrist, Siegfried Rödl, Andrea Skrabl‐Baumgartner, Matthias Sperl, Laura Stampfer, Volker Strenger, Holger Till, Andreas Trobisch, Sabine Löffler, Antonio Salas, Fernando Álvez González, Cristina Balo Farto, Ruth Barral‐Arca, María Barreiro Castro, Xabier Bello, Mirian Ben García, Sandra Carnota, Miriam Cebey‐López, María José Currás-Tuala, Carlos Durán Suárez, Luisa García Vicente, Alberto Gómez‐Carballa, José Gómez Rial, Pilar Leboráns Iglesias, Nazareth Martinón-Torres, José María Martinón Sánchez, Belén Mosquera Pérez, Jacobo Pardo‐Seco, Lidia Piñeiro Rodríguez, Sara Pischedda, Sara Rey Vázquez, Carmen Rodrı́guez-Tenreiro, Lorenzo Redondo-Collazo, Miguel Sadiki Ora, Sonia Serén Fernández, Cristina Serén Trasorras, Marisol Vilas Iglesias, Mojca Kolnik, Katarina Vincek, Tina Plankar Srovin, Natalija Bahovec, Petra Prunk, Veronika Osterman, Tanja Avramoska, Anda Balode, Arta Bārzdiņa, Dãrta Deksne, Dace Gardovska, Dagne Grãvele, Ilze Grope, Anija Meiere, Ieva Nokalna, Jana Pavāre, Zanda Pučuka, Katrīna Selecka, Aleksandra Sidorova, Dace Svile, Urzula Nora Urbāne, Maria Tambouratzi, Antonis Marmarinos, Marietta Xagorari, Kelly Syggelou, Ronald de Groot, Michiel van der Flier, Marien I. de Jonge, Koen van Aerde, Wynand Alkema, Bryan van den Broek, Jolein Gloerich, Alain J. van Gool, Stefanie Henriet, Martijn Huijnen, Ria Philipsen, Esther Willems
6Citations signalées — pas une note de qualité
13Institutions déclarées
7Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Studies on procalcitonin (PCT) for identifying sepsis were published as early as 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show PCT to be superior to CRP in differentiating invasive infections such as sepsis from viral infections, especially early in the disease course. However, its actual use in clinical practice is poorly documented. Our aim was to study the use of PCT in febrile children attending the ED across Europe and compare this to the use of CRP. METHODS: The MOFICHE/PERFORM study, a prospective multicenter study, took place at 12 European EDs in eight countries and included febrile children < 18 years. In this secondary analysis of nine participating EDs that used PCT, descriptive analyses were performed, describing the use of PCT in all febrile children and for different age groups, foci of fever and fever duration. RESULTS: In total, 31,612 pediatric febrile episodes were available for analyses. Blood tests were performed in 15,812 (50.0%, range 9.6-92.6%)) febrile episodes. CRP was included in 98.3% of blood tests (range between hospitals 80-100%), while PCT was included in only 3.9% (range 0.1-86%). PCT was most often performed in children below 3 months (12.0% versus 3.6% in older children, p < 0.001). PCT was used slightly more often in children with fever less than 24 h in comparison to children with a duration of fever ≥ 24 h (4.9% versus 3.4%, p < 0.001). Regarding clinical alarming signs, PCT was used most often in children with meningeal signs (7.0%) or a non-blanching rash (10.9%). CONCLUSION: Actual PCT use in febrile children at European EDs is limited and varies largely between hospitals. Possible explanations include lack of guidelines, limited availability, higher costs and lack of readiness to adapt new clinical strategies.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study
- Date Crossref
- 01/03/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Sepsis Diagnosis and TreatmentNeonatal and Maternal InfectionsImmune Response and Inflammation