Accès ouvert
2025
article
OpenAlex
Dorine Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud Nijman et autres
BACKGROUND: Studies on procalcitonin (PCT) for identifying sepsis were published as early as 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show PCT to be superior to CRP in differentiating invasive infections such as sepsis …
nl, gb, de, at, si, lv, gr
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Accès ouvert
2023
article
OpenAlex
Heather Jackson, Judith Zandstra, Stephanie Menikou, Melissa Shea Hamilton et autres
BACKGROUND: Differentiating between self-resolving viral infections and bacterial infections in children who are febrile is a common challenge, causing difficulties in identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights and can lead to the identification …
gb, nl, ch, de, gr, si, au, Gambie, lv, at, es
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Accès ouvert
2023
article
OpenAlex
Laura Kolberg, Aakash Khanijau, Fabian Johannes Stanislaus van der Velden, Jethro Adam Herberg et autres
BACKGROUND: Optimization of antimicrobial stewardship is key to tackling antimicrobial resistance, which is exacerbated by overprescription of antibiotics in pediatric emergency departments (EDs). We described patterns of empiric antibiotic use in European EDs and characterized appropriateness and consistency of prescribing. METHODS: Between …
de, gb, nl, es, si, ch, gr, at, Gambie, fr, us
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Accès ouvert
2023
article
OpenAlex
Priyen Shah, Marie A Voice, Leonides A. Calvo-Bado, Irene Rivero Calle et autres
The PERFORM study aimed to understand causes of febrile childhood illness by comparing molecular pathogen detection with current clinical practice. Febrile children and controls were recruited on presentation to hospital in 9 European countries 2016–2020. Each child was assigned a standardized diagnostic …
gb, es, gr, de, si, lv, at, Gambie, nl, ch, us, fr, tw
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Accès ouvert
2023
article
OpenAlex
Esther Willems, Jolein Gloerich, Anouk Suppers, Michiel van der Flier et autres
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in …
nl, gb, es
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Accès ouvert
2023
article
OpenAlex
Chantal D. Tan, Clementien L. Vermont, Joany M. Zachariasse, Ulrich von Both et autres
Children constitute 6-10% of all patients attending the emergency department (ED) by emergency medical services (EMS). However, discordant EMS use in children occurs in 37-61% with fever as an important risk factor. We aimed to describe EMS utilisation among febrile children attending …
nl, de, gr, gb, at, si
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Accès ouvert
2023
erratum
OpenAlex
Fabian Johannes Stanislaus van der Velden, Gabriella de Vries, Alexander Reid Martin, Emma J. Lim et autres
In the original published version of the above article, the names of members of the PERFORM consortium were not introduced in the authorship section. The names are now properly displayed. The complete consortium list has been added as Supplementary material to the …
gb, nl, de, es, si, ch, gr, lv, at, Gambie
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Accès ouvert
2022
article
OpenAlex
Fabian Johannes Stanislaus van der Velden, Gabriella de Vries, Alexander J. Martin, Emma J. Lim et autres
To assess and describe the aetiology and management of febrile illness in children with primary or acquired immunodeficiency at high risk of serious bacterial infection, as seen in emergency departments in tertiary hospitals. Prospective data on demographics, presenting features, investigations, microbiology, management, …
gb, nl, de, es, si, ch, gr, lv, at, Gambie
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Accès ouvert
2022
article
OpenAlex
Chantal D. Tan, Eline E. P. L. van der Walle, Clementien L. Vermont, Ulrich von Both et autres
Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. There is practice variation in management due to differences in guidelines and their usage and adherence. We aimed to assess whether …
nl, de, gb, gr, at, si, lv
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