Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function
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Le résumé fourni par la source
As effectors of interactions between genes and the environment, plasma proteins can monitor homeostasis and reflect the aging state of an organism. However, biomarkers of aging that are associated with homeostasis are still unclear. This study investigates the phenotype-related plasma proteome profiles of healthy individuals and to identify proteins that are specifically related to aging and physiological indices and their expression patterns across the lifespan. From September 2020 to March 2021, 71 participants aged over 20 to 100 years were enrolled in this cross-sectional study. Data were analyzed from April 2021 to December 2023. The plasma proteome was analyzed to identify proteins that are specifically related to aging and their expression patterns across the lifespan. Then, hub proteins were screened through correlation of aging proteins with physiological and biochemical phenotypes. Based on levels of plasma proteins, physiological indices are associated with age. Additionally, these differences in protein expression correlate with age and physiological indices. Finally, we identified 20 hub proteins that correlate with both physiological indices and age, and these proteins are involved in oxidative stress, inflammation and metabolism. Bibliometric analysis confirmed that 8 hub proteins (CD44, CD14, IGF2, CFD, LBP, IGFBP3, EFEMP1, and AHSG) associated with age affect organ function by mediating homeostasis. Plasma proteins associated with both age and physiological indices are involved in oxidative stress, inflammation, and metabolism. This is the first investigation to link aging and homeostasis based on plasma proteins.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function
- Date Crossref
- 10/02/2025
- Éditeur
- Ivyspring International Publisher
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese PLA General Hospital pays non établi dans la noticeÉtablissement de santé
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Hebei Medical University Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Beijing Children’s Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing Aerospace General Hospital pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Laboratory pays non établi dans la noticeStructure de recherche
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Beijing IPE Center for Clinical Laboratory CO Department of Research & Development pays non établi dans la noticeStructure de recherche
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Capital Medical University Beijing Children's Hospital pays non établi dans la noticeUniversité ou école supérieure
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Beijing Hospital General Practice Department pays non établi dans la noticeÉtablissement de santé
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The Key Laboratory of Geriatrics pays non établi dans la noticeStructure de recherche
Chinese PLA General Hospital, Department of Biochemistry and Molecular Biology — Hebei Medical University et Beijing Children’s Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.