Accès ouvert déclaré
2025
article
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
Robert Bentham, Thomas P. Jones, James R. Black, Carlos Martínez‐Ruiz, Michelle Dietzen, Maria Litovchenko, Kerstin Thol, Thomas B.K. Watkins, C. Bailey, Oriol Pich, Zhihui Zhang, Peter Van Loo, Mariam Jamal‐Hanjani, Takahiro Karasaki, Abigail Bunkum, Sonya Hessey, Wing Kin Liu, Nicolai J. Birkbak, Alexander M. Frankell, Ariana Huebner, Clare Puttick, Crispin T. Hiley, David Moore, Dhruva Biswas, Emilia L. Lim, Kristiana Grigoriadis, Maise Al Bakir, Olivia Lucas, Roberto Vendramin, Sophia Ward, S. Harries, Simone Zaccaria, Rija Zaidi, Lucrezia Patruno, Despoina Karagianni, Sergio A. Quezada, Supreet Kaur Bola, Martin Förster, Siow Ming Lee, Corentin Richard, Cristina Naceur‐Lombardelli, Francisco Gimeno-Valiente, Krupa Thakkar, Monica Sivakumar, Nnennaya Kanu, Ieva Usaite, Sadegh Saghafinia, Selvaraju Veeriah, Sharon Vanloo, Antonia Toncheva, Paulina Prymas, Michalina Magala, Elizabeth Keene, Michelle Leung, Gareth A. Wilson, Rachel Rosenthal, Andrew Rowan, Claudia Lee, Emma Colliver, Katey S.S. Enfield, Mihaela Angelova, Cian Murphy, Maria Zagorulya, Teresa Marafioti, Elaine Borg, Mary Falzon, Reena Khiroya, Yien Ning Sophia Wong, Emilie Martinoni Hoogenboom, Fleur Monk, James W. Holding, Junaid Choudhary, Kunal Bhakhri, Pat Gorman, Robert Stephens, Maria Chiara Pisciella, Steve Bandula, Jérôme Nicod, Angela Dwornik, Angeliki Karamani, Benny Chain, David R. Pearce, Georgia Stavrou, Gerasimos-Theodoros Mastrokalos, Helen L. Lowe, James L. Reading, John A. Hartley, Kayalvizhi Selvaraju, Leah Ensell, Mansi Shah, Piotr Pawlik, Samuel Gamble, Seng Kuong Anakin Ung, Victoria J. Spanswick, Yin Wu, J.F. Lester, Sean Dulloo, Dean A. Fennell, Amrita Bajaj, Apostolos Nakas, Azmina Sodha-Ramdeen, Mohamad Tufail, Molly Scotland, Rebecca Boyles, Sridhar Rathinam, Claire Wilson, Gurdeep Matharu, Jacqui Shaw, Ekaterini Boleti, Heather Cheyne, Mohammed S. Khalil, Shirley Richardson, Tracey Cruickshank, Gillian Price, Keith M. Kerr, Sarah Benafif, Dionysis Papadatos-Pastos, James M. Wilson, Tanya Ahmad, Jack French, Kayleigh Gilbert, Babu Naidu, Akshay J. Patel, Gary Middleton, Aya Osman, Mandeesh Sangha, Gerald Langman, Helen Shackleford, Madava Djearaman, Angela Leek, Jack Davies Hodgkinson, Nikki Totton, Philip Crosbie, Eustace Fontaine, Felice Granato, Juliette Novasio, Kendadai Rammohan, Leena Dennis Joseph, Paul Bishop, Vijay V. Joshi, Sara Waplington, Katherine D. Brown, Mathew Carter, Anshuman Chaturvedi, Pedro Oliveira, Colin R. Lindsay, Fiona Blackhall, Yvonne Summers, Matthew Krebs, António Paiva‐Correia, Jonathan Tugwood, Caroline Dive, Hugo J.W.L. Aerts, Roland F. Schwarz, Tom L. Kaufmann, Zoltán Szállási, Miklós Dióssy, Roberto Salgado, Jonas Demeulemeester, Carla Castignani, Stephan Beck, George Kassiotis, Imran Noorani, Clare E. Weeden, Eva Grönroos, Jacki Goldman, Mickael Escudero, Philip Hobson, Stefan Boeing, Tamara Denner, Vittorio Barbè, Wei-Ting Lu, William Hill, Yutaka Naito, Erik Sahai, Zoe Ramsden, Emma Nye, Richard Stone, Jayant K. Rane, Jeanette Kittel, Kerstin Haase, Rachel Scott, Karl S. Peggs, Catarina Veiga, Gary Royle, Charles‐Antoine Collins‐Fekete, Francesco Fraioli, Paul Ashford, Arjun Nair, Alexander James Procter, Asia Ahmed, Magali N. Taylor, David Lawrence, Davide Patrini, Neal Navani, Ricky M. Thakrar, Sam M. Janes, Zoltán Káplár, Allan Hackshaw, Camilla Pilotti, Rachel Leslie, Anne-Marie Hacker, Sean D. Smith, Anca Grapa, Hanyun Zhang, Khalid AbdulJabbar, Xiaoxi Pan, Yinyin Yuan, David Chuter, Mairead MacKenzie, Serena Chee, Aiman Alzetani, Judith Cave, Eric Lim, Andrew G. Nicholson, Paulo De Sousa, Simon Jordan, Alexandra Rice, Hilgardt Raubenheimer, Harshil Bhayani, Lyn Ambrose, Anand Devaraj, Hema Chavan, Sofina Begum, Silviu Buderi, Daniel Kaniu, Mpho Malima, Sarah Booth, Nadia Fernandes, Pratibha Shah, Chiara Proli, Madeleine Hewish, Sarah Danson, Michael Shackcloth, Lily Robinson, Peter Russell, Kevin G. Blyth, Andrew Kidd, Craig Dick, John Le Quesne, Allan D. Kirk, Mo Asif, Rocco Bilancia, Nikos Kostoulas, Jennifer Whiteley, Mathew Thomas, J. C. Ambrose, P. Arumugam, Emma L. Baple, M. Bleda, J. M. Boissiere, C. R. Boustred, Helen Brittain, M. J. Caulfield, G. C. Chan, C. E. H. Craig, Louise C. Daugherty, Anna de Burca, A. Devereau, Greg Elgar, R. E. Foulger, Tom Fowler, Pedro Furió‐Tarí, J. M. Hackett, Dina Halai, Angela Hamblin, Seton Henderson, J. E. Holman, Tim Hubbard, Kristina Ibáñez, R. Jackson, L. J. Jones, D. Kasperaviciute, Melis Kayikci, L. Lahnstein, Lovett Lawson, S. E. A. Leigh, I. U. S. Leong, F. J. Lopez, F. Maleady-Crowe, Jeffrey B. Mason, Ellen M. McDonagh, Loukas Moutsianas, Michael Mueller, Nirupa Murugaesu, Anna C. Need, Chris A. Odhams, Christine Patch, D. Perez-Gil, Dimitris Polychronopoulos, J. Pullinger, T. Rahim, A. Rendon, Pablo Riesgo-Ferreiro, T. Rogers, Mina Ryten, K. Savage, K. Sawant, Richard H. Scott, A. Siddiq, A. Sieghart, Damian Smedley, Katherine R. Smith, A. Sosinsky, W. Spooner, H. E. Stevens, Alexander Stuckey, Răzvan Sultana, Ellen Thomas, Simon R. Thompson, Carolyn Tregidgo, Arianna Tucci, E. Walsh, S. A. Watters, M. J. Welland, Elena Williams, Katarzyna Witkowska, Scott Wood, Magdalena Zarowiecki, Charles Swanton, Nicholas McGranahan
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76Institutions déclarées
10Pays d’affiliation déclarés
Résumé fourni par la source
Recognition and elimination of pathogens and cancer cells depend on the adaptive immune system. Thus, accurate quantification of immune subsets is vital for precision medicine. We present immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell and B cell fractions, class switching and clonotype diversity from whole-genome sequencing data at depths as low as 5× coverage. By applying ImmuneLENS to the 100,000 Genomes Project, we identify genes enriched with somatic mutations in T cell-rich tumors, significant sex-based differences in circulating T cell fraction and demonstrated that the circulating T cell fraction in patients with cancer is significantly lower than in healthy individuals. Low circulating B cell fraction was linked to increased cancer incidence. Finally, circulating T cell abundance was more prognostic of 5-year cancer survival than infiltrating T cells.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
- Date Crossref
- 18/02/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Immune Cell Function and InteractionImmune cells in cancerAtherosclerosis and Cardiovascular Diseases