An in vivo and in silico predictive study on the toxicological and modulatory effects of abused substances on sperm quality and testicular function in Wistar rats
Rattachement africain : Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Some compounds like Opioids that are commonly used may affect the biological system in addition to having a high potential for addiction. Objective: This study assessed the effects of commonly misused substances on sperm quality and testicular function in Wistar rats. Material and Methods: Twenty-five Wistar rats weighing an average of 120 ± 0.1 g were randomly assigned to five treatment groups and were orally administered with water for the control, carbonated sugar drink, 150, 300, and 300 mg/kg body weight doses of menthol, monosodium glutamate, and tramadol respectively. The rats were euthanized 24 hours after the last day of the thirty-day treatment. Biochemical assays were on carried out the plasma and testicular homogenate. Results: There was a significant increase (p<0.05) in testosterone, FSH, LH, HDL, TG, phospholipids, glycogen, reduced glutathione concentration, sperm total count; %testicular weight change, and; there was also a significant decrease in the %tail defect, and %non-motile sperm across the treatment groups compared to the control. Contrary, there was a significant increase (p<0.05) in the testicular ACP and Na-K ATPases activities but MDA levels decreased significantly across treatment groups. The ouabain-α-ATPase complex’s binding energy is comparable to that of the α-ATPase complexes with tramadol, glucose, menthol, and MSG, respectively. Conclusion: The improved sperm quality and testicular function show that these compounds were not harmful to the reproductive functions of Wistar rats. The docking analysis corroborated the effects of ATPase activity modulation on sperm motility.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- An in vivo and in silico predictive study on the toxicological and modulatory effects of abused substances on sperm quality and testicular function in Wistar rats Un estudio predictivo in vivo e in silico sobre los efectos toxicológicos y moduladores de las sustancias de abuso sobre la calidad del esperma y la función testicular en ratas Wistar Um estudo preditivo in vivo e in silico sobre os efeitos toxicológicos e moduladores de substâncias de abuso na qualidade do esperma e na função testicular em ratos Wistar
- Date Crossref
- 06/06/2024
- Éditeur
- Universidad Nacional de Colombia
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Landmark University Department of Animal Science Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Lagos Department of Chemistry University of Lagos, Nigéria (code pays fourni par la source)Université ou école supérieure
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Bowen University and Computational Biochemistry Research Laboratory (PMTCB‑RL) Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Ilorin Department of Veterinary Physiology and Biochemistry University of Ilorin, Nigéria (code pays fourni par la source)Université ou école supérieure
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College of Pure and Applied Sciences Department of Biochemistry Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Animal Science — Landmark University (Nigéria), Department of Chemistry — University of Lagos (University of Lagos, Nigéria) et and Computational Biochemistry Research Laboratory (PMTCB‑RL) — Bowen University (Nigéria), avec 2 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.